Rabbit anti-Human ACER1 Polyclonal Antibody | anti-Acer1 antibody
ACER1, CT (ACER1, ASAH3, Alkaline ceramidase 1, Acylsphingosine deacylase 3, N-acylsphingosine amidohydrolase 3)
Gene Names
Acer1; Cer1; Asah3; AI662009; Alkcdase1; 2310024P18Rik
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Affinity PurifiedPurified by Protein A affinity chromatography.
Synonyms
ACER1; Polyclonal Antibody; CT (ACER1; ASAH3; Alkaline ceramidase 1; Acylsphingosine deacylase 3; N-acylsphingosine amidohydrolase 3); Anti -ACER1; anti-Acer1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Human
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Applicable Applications for anti-Acer1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunogen
ACER1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-264 amino acids from the C-terminal region of human ACER1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Related Product Information for anti-Acer1 antibody
Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).
Product Categories/Family for anti-Acer1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
32,082 Da
NCBI Official Full Name
alkaline ceramidase 1
NCBI Official Synonym Full Names
alkaline ceramidase 1
NCBI Official Symbol
Acer1
NCBI Official Synonym Symbols
Cer1; Asah3; AI662009; Alkcdase1; 2310024P18Rik
NCBI Protein Information
alkaline ceramidase 1; maCER1; alkCDase 1; alkaline cdase 1; acylsphingosine deacylase 3; N-acylsphingosine amidohydrolase 3
UniProt Protein Name
Alkaline ceramidase 1
Protein Family
UniProt Gene Name
Acer1
UniProt Synonym Gene Names
Asah3; AlkCDase 1; Alkaline CDase 1; maCER1
UniProt Entry Name
ACER1_MOUSE
Uniprot Description
ACER1: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids. Belongs to the alkaline ceramidase family.
Protein type: Membrane protein, integral; Lipid Metabolism - sphingolipid; EC 3.5.1.23; Membrane protein, multi-pass; Endoplasmic reticulum; Hydrolase
Cellular Component: membrane; endoplasmic reticulum; integral to membrane
Molecular Function: hydrolase activity; ceramidase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Biological Process: regulation of lipid metabolic process; sphingolipid metabolic process; response to alkalinity; sphingolipid biosynthetic process; sphingosine biosynthetic process; ceramide catabolic process; lipid metabolic process; ceramide metabolic process; cell differentiation
Research Articles on Acer1
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Product Notes
The Acer1 acer1 (Catalog #AAA6007441) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ACER1, CT (ACER1, ASAH3, Alkaline ceramidase 1, Acylsphingosine deacylase 3, N-acylsphingosine amidohydrolase 3) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ACER1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the Acer1 acer1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ACER1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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