Western Blot (WB)
(Western blot analysis of XPO1 antibody (C-term) in mouse bladder tissue lysates (35ug/lane). XPO1 (arrow) was detected using the purified Pab.)
Rabbit anti-Human, Mouse Exportin 1 Polyclonal Antibody | anti-emb antibody
Exportin 1, CT (XPO1, Chromosome Region Maintenance 1 Protein Homolog, CRM1, DKFZp686B1823, emb, Exp1, Exportin-1)
Purified by ammonium sulfate precipitation.
Purified by ammonium sulfate precipitation.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
Western Blot (WB)
(Western blot analysis of XPO1 antibody (C-term) in mouse bladder tissue lysates (35ug/lane). XPO1 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of XPO1 antibody (C-term) in mouse bladder tissue lysates (35ug/lane). XPO1 (arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human brain tissue reacted with XPO1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human brain tissue reacted with XPO1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Flow Cytometry (FC/FACS)
(Flow cytometric analysis of widr cells using XPO1 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(Flow cytometric analysis of widr cells using XPO1 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
NCBI and Uniprot Product Information
Uniprot Description
Function: Receptor for the leucine-rich nuclear export signal (NES). Binds cooperatively to the NES on its target protein and to the small GTPase Ran in its active GTP-bound form. Required for the function or maintenance of certain tissues such as brain and gut. Involved in the export of dl from the nucleus to the cytoplasm. Ref.1 Ref.2 Ref.7
Subunit structure: Interacts with Clbn (via its N-terminus)
By similarity. Interacts with mbo to form components of the nuclear pore complex, of which Nup214 is also a member. Interacts with target proteins containing NES sequences such as actin and dl. Ref.1 Ref.7
Subcellular location: Nucleus › nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side Ref.2 Ref.7.
Tissue specificity: High expression observed in the developing embryonic brain, hind gut and posterior spiracles shortly before dorsal closure; and in the ventral nerve cord, midgut and somatic musculature shortly after dorsal closure. Expression increases when the tissue is well developed. Ref.1
Developmental stage: Highly expressed both maternally and zygotically. Ref.1
Miscellaneous: Activity inhibited by leptomycin B, which disrupts interaction with the NES and RanGTP.
Sequence similarities: Belongs to the exportin family.Contains 1 importin N-terminal domain.
Research Articles on emb
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Product Notes
The emb emb (Catalog #AAA6004874) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Exportin 1, CT (XPO1, Chromosome Region Maintenance 1 Protein Homolog, CRM1, DKFZp686B1823, emb, Exp1, Exportin-1) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Exportin 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Dilution: ELISA: 1:1,000 Western Blot: 1:50-1:100. Researchers should empirically determine the suitability of the emb emb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Exportin 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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