Testing Data
(Detection of GRK1 with MAB4498. Lysates from human HeLa, mouse Baf-3, and rat L6 cells were resolved by SDS-PAGE. Following electrophoresis, proteins were transferred to an Immobilon-P membrane and immunoblotted with 1 μg/mL anti-GRK1, as described in Protocols for Immunoblotting.)
Mouse Rhodopsin Kinase 1 Monoclonal Antibody | anti-GRK1 antibody
Rhodopsin Kinase 1 (G Protein-Associated Rhodopsin Kinase 1, GRK1)
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
Dilution: Western Blot: 1ug/mL
Testing Data
(Detection of GRK1 with MAB4498. Lysates from human HeLa, mouse Baf-3, and rat L6 cells were resolved by SDS-PAGE. Following electrophoresis, proteins were transferred to an Immobilon-P membrane and immunoblotted with 1 μg/mL anti-GRK1, as described in Protocols for Immunoblotting.)
Testing Data
(Detection of GRK1 with MAB4498. Lysates from human HeLa, mouse Baf-3, and rat L6 cells were resolved by SDS-PAGE. Following electrophoresis, proteins were transferred to an Immobilon-P membrane and immunoblotted with 1 μg/mL anti-GRK1, as described in Protocols for Immunoblotting.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq]
Uniprot Description
GRK1: a Ser/Thr of the GRK family. Phosphorylates and inactivates photon-activated rhodopsin. LOF mutations lead to type 2 Oguchi disease, a form of night blindness. A link between RHOK and retinitis pigmentosa is now thought to be unlikely
Protein type: EC 2.7.11.14; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; AGC group; GRK family; GRK subfamily
Chromosomal Location of Human Ortholog: 13q34
Molecular Function: G-protein coupled receptor kinase activity; rhodopsin kinase activity; ATP binding; protein kinase activity
Biological Process: rhodopsin mediated signaling; phototransduction, visible light; post-embryonic retina morphogenesis in camera-type eye; regulation of rhodopsin mediated signaling; visual perception; protein amino acid autophosphorylation; photoreceptor cell morphogenesis; positive regulation of phosphorylation; regulation of G-protein coupled receptor protein signaling pathway; negative regulation of apoptosis
Disease: Oguchi Disease 2
Research Articles on GRK1
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Product Notes
The GRK1 grk1 (Catalog #AAA600370) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Rhodopsin Kinase 1 (G Protein-Associated Rhodopsin Kinase 1, GRK1) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Rhodopsin Kinase 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Dilution: Western Blot: 1ug/mL. Researchers should empirically determine the suitability of the GRK1 grk1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Rhodopsin Kinase 1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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