Rabbit anti-Human RAP80 Polyclonal Antibody

RAP80, CT (BRCA1-A Complex Subunit RAP80, Receptor-associated Protein 80, Retinoid X Receptor-interacting Protein 110, Ubiquitin Interaction Motif-containing Protein 1, UIMC1, RXRIP110)

Cat. Num. AAA6000134

• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: RAP80; Polyclonal Antibody; CT (BRCA1-A Complex Subunit RAP80; Receptor-associated Protein 80; Retinoid X Receptor-interacting Protein 110; Ubiquitin Interaction Motif-containing Protein 1; UIMC1; RXRIP110); Anti -RAP80; anti-RAP80 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human UIMC1. Species sequence homology: mouse
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-RAP80 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Western Blot and Immunohistochemistry.; Dilution: Western Blot: 2ug/ml; Immunohistochemistry (Formalin-fixed, paraffin-embedded): 5ug/ml
• Immunogen: Synthetic peptide corresponding to17aa from near the C-terminal of human RAP80 (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Testis (formalin-fixed, paraffin-embedded) stained with UIMC1 antibody at 5ug/ml followed by biotinylated goat rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)

Immunohistochemistry (IHC)

(Immunohistochemistry of RAP80 in human spleen tissue with RAP80 antibody at 2.5ug/ml.)

Related Product Information for anti-RAP80 antibody

Receptor Associated Protein 80 (RAP80) is a 79.8kD nuclear acidic protein. RAP80 acts as a transcriptional repressor, inhibiting the interaction of NR6A1 with the co-repressor NCOR1. Studies have demonstrated that RAP80 is recruited by CCDC98 to BRCA1 allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Along with CCDC98, RAP80 is required for DNA damage resistance, G2-M checkpoint control and DNA repair.

RAP80 is highly expressed by germ cells of the testis and is also expressed in the ovary, thymus and heart. Research has shown the existence of at least four isoforms of RAP80.

Product Categories/Family for anti-RAP80 antibody

Antibodies; Abs to Binding Proteins