Mouse anti-Human MBL Monoclonal Antibody | anti-MBL antibody

MBL, Human, mAb 3E7, FITC

Cat. Num. AAA584398

• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay, Western Blot
• Synonyms: MBL; Monoclonal Antibody; Human; mAb 3E7; FITC; anti-MBL antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Mouse IgG1
• Form/Format: 1 ml (100 ug/ml) 0.2 um filtered FITC conjugated antibody solution in PBS, containing 1% bovine serum albumin and 0.02% sodium azide.
• Sequence Length: 333

• Applicable Applications for anti-MBL antibody: F, Flow Cytometry (FC/FACS), Immunoassay (IA), Western Blot (WB)
• Application Notes: Application Use: For Western blotting, flow cytometry and immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
• Conjugate: FITC
• Preparation and Storage: Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for one year.

Related Product Information for anti-MBL antibody

Product Description: Mannose Binding Lectin (MBL) also called mannose- or mannan-binding protein (MBP) is a member of the group of collectins. MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N-acetylglucosamine on pathogens. MBL contains a cysteine rich, a collagen like and a carbohydrate recognition domain. It forms a complex with C1r/C1s like serine proteases designated MASPs that proteolytically cleave C4, C2 and C3. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways. The MBL-MASP pathway (better known as the lectin pathway) is antibody and C1q-independent. MBL exhibits complement-dependent antibacterial activity and acts directly as an opsonic and therefore plays an important role in innate immunity. MBL is synthesized by hepatocytes and has been isolated from the liver or serum of various vertebrate species.

References

1. Muto, S et al; Biological activities of human mannose-binding lectin bound to two different ligand sugar structures, Lewis A and Lewis B antigens and high-mannose type oligosaccharides. Biochimica et Biophysica Acta 2001, 1527: 39 2. Matsushita, M et al; Human mannose-binding protein is identical to a component of Ra-reactive factor. Biochem Biophys Res Commun 1992, 183: 645
3. Hisano, S et al; Mesangial IgA2 deposits and lectin pathway-mediated complement activation in IgA glomerulonephritis. Am J Kidney Dis 2001, 38: 1082
4. Vries de, B et al; The mannose-binding lectin-pathway is involved in complement activation in the course of renal ischemia-reperfusion injury. Am J Pathol 2004, 165: 1677
5. Nauta, A et al; Mannose-binding lectin engagement with late apoptotic and necrotic cells. Eur J Immunol 2003, 33 : 2853
6. Nauta, A et al ; Opsonization with C1q and Mannose-binding lectin targets apoptotic cells to dendritic cells. J Immunol 2004, 173: 3044

NCBI and Uniprot Product Information

• NCBI GI #: 154353611
• Molecular Weight: 35,875 Da
• NCBI Official Full Name: Mbl
• UniProt Protein Name: Mbl
• Protein Family: MreB-like protein
• UniProt Gene Name: mbl
• UniProt Synonym Gene Names: RBAM_033610
• UniProt Entry Name: A7Z9L4_BACA2