Structure
UNC 926, inhibitor
UNC 926 hydrochloride
Purity
97.0%
Synonyms
UNC 926; UNC 926 hydrochloride; inhibitor
Purity/Purification
97.0%
Form/Format
POWDER
CAS
1184136-10-4
Formula
C16H21BrN2O.HCl
Pathways
Chromatin/Epigenetic
Target
L3MBTL1
Smiles
C1CCN(C1)C1CCN(CC1)C(=O)c1cc(ccc1)Br
Receptor
L3MBTL1
Bioactivity
UNC-926 inhibits L3MBTL1 with an IC50 of 3.9 muM. UNC-926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3, with a decrease in affinity for the other MBT domains and no binding to CBX7. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1. It selectively inhibits the L3MBTL13xMBT-H4K20me1 interaction in a dose-dependent manner. UNC-926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC-926 for L3MBTL1 over 53BP1.
Solubility Note
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
Preparation and Storage
For 3 years at -20 degree C (powder)
For 2 years -80 degree C in solvent.
For 2 years -80 degree C in solvent.
Structure
Structure
References
1. Herold JM, et al. Structure-activity relationships of methyl-lysine reader antagonists. MedChemComm. 2012; 3 (45):45-51.
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Product Notes
The UNC 926 (Catalog #AAA579917) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "UNC 926, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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