Ganodermanondiol, Inhibitor

Ganodermanondiol

Purity

98.00%

Synonyms

Ganodermanondiol; inhibitor

Ordering
Cat. Num. AAA5760399 For Research Use Only!

Purity/Purification

98.00%

Form/Format

Solid. Powder

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C30H48O3

SMILES

C[C@H](CC[C@@H](C(C)(C)O)O)[C@H]1CC[C@@]2([C@@]1(CC=C3C2=CC[C@@H]4[C@@]3(CCC(=O)C4(C)C)C)C)C

CAS Number

107900-76-5

Target & IC50

Nrf2
HIV
AMPK

In Vitro

Ganodermanondiol protected human liver-derived HepG2 cells through nuclear factor-E2-related factor 2 (Nrf2) pathway-dependent heme oxygenase-1 expressions. Moreover, Ganodermanondiol increased cellular glutathione levels and the expression of the glutamine-cysteine ligase gene in a dose-dependent manner. Furthermore, Ganodermanondiol exposure enhanced the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) and its upstream kinase activators, LKB1 and Ca(2+)/calmodulin-dependent protein kinase-II (CaMKII)[1]

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Related Product Information for Ganodermanondiol, inhibitor

Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK.

Product Categories/Family for Ganodermanondiol, inhibitor

Immunology/Inflammation; Nrf2; Microbiology&virology; PI3K/Akt/mTOR signaling

References

Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant enzymes.Food Chem Toxicol. 2013 Mar;53:317-24.
Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant enzymes.Food Chem Toxicol. 2013 Mar;53:317-24.
Anticomplement activity of terpenoids from the spores of Ganoderma lucidum.Planta Med. 2001 Dec;67(9):811-4.

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Product Notes

The Ganodermanondiol (Catalog #AAA5760399) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Ganodermanondiol, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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Ganodermanondiol, Inhibitor