Structure
PI3K/mTOR-2, inhibitor
PI3K/mTOR Inhibitor-2
Purity
98.00%
Synonyms
PI3K/mTOR-2; PI3K/mTOR Inhibitor-2; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 8.33mg/mL (17.40mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C20H13ClF2N4O4S
SMILES
FC1=CC(F)=C(S(=O)(NC2=CC(C(C=C3)=CN4C3=NC=C(Cl)C4=O)=CN=C2OC)=O)C=C1
CAS Number
1848242-58-9
Target & IC50
PI3Kalpha: ic50 3.4nM
PI3Kbeta: ic50 34nM
PI3Kdelta: ic50 16nM
PI3Kgamma: ic50 1nM
mTOR: ic50 4.7nM
PI3Kbeta: ic50 34nM
PI3Kdelta: ic50 16nM
PI3Kgamma: ic50 1nM
mTOR: ic50 4.7nM
In Vitro
PI3K/mTOR Inhibitor-2(Compound 31) exhibited high enzyme activity against PI3K and mTOR, potent suppression of Akt and p70s6k phosphorylation in cell assays, and good pharmacokinetic profile.
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for PI3K/mTOR-2, inhibitor
PI3K/mTOR Inhibitor-2 is a potent dual inhibitor of pan-PI3K/mTOR(PI3Kalpha/PI3Kbeta/PI3Kdelta/PI3Kgamma/mTOR with IC50s of 3.4/34/16/1/4.7nM).
Product Categories/Family for PI3K/mTOR-2, inhibitor
References
Yu T, et al. Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR. ACS Med Chem Lett. 2018 Feb 27;9(3):256-261.
Yu T, et al. Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR. ACS Med Chem Lett. 2018 Feb 27;9(3):256-261.
Yu T, et al. Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR. ACS Med Chem Lett. 2018 Feb 27;9(3):256-261.
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Product Notes
The PI3K/mTOR-2 (Catalog #AAA5753690) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PI3K/mTOR-2, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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