HSP40/Hdj2 recombinant protein
HSP40/Hdj2 (human), (recombinant)
Gene Names
DNAJA1; DJ-2; DjA1; HDJ2; HSDJ; HSJ2; HSPF4; NEDD7; hDJ-2
Applications
Western Blot
Purity
>=90% (SDS-PAGE; Western blot)Purified by multi-step chromatography
Synonyms
HSP40/Hdj2; HSP40/Hdj2 (human); (recombinant); HSP40/Hdj2 recombinant protein
Host
E Coli
Purity/Purification
>=90% (SDS-PAGE; Western blot)
Purified by multi-step chromatography
Purified by multi-step chromatography
Form/Format
Liquid. In TBS containing 1mM DTT
Applicable Applications for HSP40/Hdj2 recombinant protein
Western Blot (WB)
Preparation and Storage
For long term storage, store at -80 degree C
Shipping: Shipped on Dry Ice
Shipping: Shipped on Dry Ice
Related Product Information for HSP40/Hdj2 recombinant protein
Hdj2 is an approximately 40 kDa member of the heat shock protein (HSP40) family, a eukaryotic homolog of the E Coli DnaJ protein. Eukaryotic DnaJ-like proteins share structural domain conservation with DnaJ, namely: 1) an N-terminal ~70 amino acid J domain, 2) a glycine- and phenylalanine-rich domain, 3) a cysteine-rich zinc finger domain, and 4) a poorly conserved C-terminal domain. The human constitutive Hdj2 protein shares full domain conservation with DnaJ, as opposed to the human inducible Hdj1 which lacks the zinc-finger domain. The HSP40 J domain regulates its interaction with HSP70 (E Coli DnaK), increasing HSP70 ATPase activity and in turn enhancing substrate binding by the HSP70 chaperone. HSP40 co-chaperones are involved in nearly all aspects of protein synthesis and secretion because of their importance in HSP70 function, and they are also thought to have an intrinsic ability to bind and fold some misfolded proteins. Hdj2 has been specifically shown to interact with Hsc70, the constitutive form of HSP70, in the biogenesis of the cystic fibrosis transmembrane conductance regulator (CFTR), mutations of which are known to cause inherited cystic fibrosis.
Product Categories/Family for HSP40/Hdj2 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
397
NCBI Official Full Name
DnaJ homolog subfamily A member 1
NCBI Official Synonym Full Names
DnaJ (Hsp40) homolog, subfamily A, member 1
NCBI Official Symbol
DNAJA1
NCBI Official Synonym Symbols
DJ-2; DjA1; HDJ2; HSDJ; HSJ2; HSPF4; NEDD7; hDJ-2
NCBI Protein Information
dnaJ homolog subfamily A member 1; HSJ-2; human DnaJ protein 2; heat shock protein J2; dnaJ protein homolog 2; heat shock 40 kDa protein 4; heat shock protein, DNAJ-like 2; neural precursor cell expressed, developmentally down-regulated 7
UniProt Protein Name
DnaJ homolog subfamily A member 1
UniProt Gene Name
DNAJA1
UniProt Synonym Gene Names
DNAJ2; HDJ2; HSJ2; HSPF4; HSJ-2; hDj-2
UniProt Entry Name
DNJA1_HUMAN
Uniprot Description
DNAJA1: Co-chaperone of Hsc70. Seems to play a role in protein import into mitochondria.
Protein type: Chaperone; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component: membrane; mitochondrion; perinuclear region of cytoplasm; cytosol; nucleus; ubiquitin ligase complex
Molecular Function: protein binding; G-protein-coupled receptor binding; low-density lipoprotein receptor binding; chaperone binding; metal ion binding; ubiquitin protein ligase binding; unfolded protein binding; Hsp70 protein binding; ATP binding
Biological Process: negative regulation of JNK activity; protein folding; positive regulation of apoptosis; DNA damage response, detection of DNA damage; response to unfolded protein; regulation of protein transport; sperm motility; response to heat; androgen receptor signaling pathway; spermatogenesis; protein refolding; negative regulation of protein ubiquitination; negative regulation of apoptosis
Research Articles on HSP40/Hdj2
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Product Notes
The HSP40/Hdj2 dnaja1 (Catalog #AAA565945) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's HSP40/Hdj2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the HSP40/Hdj2 dnaja1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HSP40/Hdj2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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