GABA B Receptor 2 Blocking Peptide | GABA B blocking peptide
GABA B Receptor 2 Peptide
Applications
Immunodepletion, Immunocompetition
Synonyms
GABA B Receptor 2; GABA B Receptor 2 Peptide; GABA-B-R2; Gamma aminobutyric acid (GABA) B receptor 2; Gb1; GPRC3A; Seven transmembrane helix receptor antibody; GABA B blocking peptide
Form/Format
Antigenic Blocking Peptide
Concentration
Quantity: 250 ug; Volume: 100 ul (varies by lot)
Sequence Length
372
Applicable Applications for GABA B blocking peptide
Immunodepletion, Immunocompetition
Application Notes
Western Blot: 1:500
Immunogen
Synthetic peptide taken within amino acid region 1-50 on human gamma-aminobutyric acid A receptor beta 2 protein.
Expression
Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.
Determinant
N-epitope
Molecular Function
Chloride channel activity; GABA-A receptor activity; Inhibitory extracellular ligand-gated ion channel activity
Structure
Binds UBQLN1. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, althoughto different extents. Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains.
Subcellular Location
Cell junction degree Synapse degree postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Preparation and Storage
-20 degree C for long term storage
Related Product Information for GABA B blocking peptide
Antigenic Blocking Peptide Gamma-aminobutyric acid receptor subunit beta-2 N-epitope
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
42,741 Da
NCBI Official Full Name
gamma-aminobutyric acid A receptor beta 2 isoform 4
NCBI Official Synonym Full Names
gamma-aminobutyric acid type A receptor beta2 subunit
NCBI Official Symbol
GABRB2
NCBI Protein Information
gamma-aminobutyric acid receptor subunit beta-2
UniProt Protein Name
Gamma-aminobutyric acid receptor subunit beta-2
UniProt Gene Name
GABRB2
UniProt Entry Name
GBRB2_HUMAN
NCBI Description
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008]
Uniprot Description
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
Research Articles on GABA B
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Product Notes
The GABA B gabrb2 (Catalog #AAA543713) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's GABA B Receptor 2 can be used in a range of immunoassay formats including, but not limited to, Immunodepletion, Immunocompetition. Western Blot: 1:500. Researchers should empirically determine the suitability of the GABA B gabrb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GABA B Receptor 2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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