Humanin Positive Control | MTRNR2L2 positive control
Humanin Positive Control
Gene Names
MTRNR2L2; HN2
Applications
Western Blot
Synonyms
Humanin; Humanin Positive Control; HN; HUNIN; MT-RNR2 antibody; MTRNR2L2 positive control
Host
Rabbit
Form/Format
Western Blot Positive Control in SDS sample buffer.
Sequence Length
28
Applicable Applications for MTRNR2L2 positive control
Western blot (WB)
Application Notes
Western Blot: 1:500
Immunogen
Purified protein
Expression
Expressed in the heart, skeletal muscles, kidney and liver. Lesser but significant expression is observed in the brain and the gastrointestinal tract. Expressed in the AD brain, where it is found in some of the large intact neurons of the occipital lobes and small and round reactive glial cells in the hippocampus.
Molecular Function
Receptor antagonist activity; Apoptosis; Leukocyte chemotaxis
Structure
Largely unstructured in aqueous solution.
Subcellular Location
Secreted; Cytoplasm
Preparation and Storage
-20 degree C for long term storage
Related Product Information for MTRNR2L2 positive control
Slot blot positive fontrol for Humanin Antibody
Overview:
Humanin is a peptide that is 21 or 24 amino acids long whether it is produced in the mitochondria or cytosol respectively (1). Humanin is encoded by the mi16S ribosomal RNA gene MT-RNR2 (2). Humanin is believed to have neuroprotective and cytoprotective effects. Studies have found humanin and humanin derivatives increase survival and physiological parameters in Alzheimer's disease models (3). Humanin is also believed to play neuroprotective roles in Huntington's deisease, prion disease and strokes (4). Humanin may playa role in various ot~er ailments including protection against oxidative stress, atherosclerotic plaque formation, heart attack and diabetes. (5, 6, 7, 8, 9).
The pan-Humanin selective antibodies were generated using a synthetic peptide corresponding to amino acid region 5-24 on human Humanin peptide. The Humanin antibodies are affinity purified over immobilized antigen based affinity chromatography. The purified immunoglobulins are prepared in stabilization buffer for long term storage. Antigenic blocking peptides, and western blot positive control in ready to use SDS-sample buffer are available. Antibodies can be conjugated to fluorophores and other secondary enzymes upon request at nominal cost. The pan-Humanin selective antibodies will label all Humanin isoforms except Humanin 9. Humanin 9-selective antibody is available for detection of only the Humanin 9 isoform.
Overview:
Humanin is a peptide that is 21 or 24 amino acids long whether it is produced in the mitochondria or cytosol respectively (1). Humanin is encoded by the mi16S ribosomal RNA gene MT-RNR2 (2). Humanin is believed to have neuroprotective and cytoprotective effects. Studies have found humanin and humanin derivatives increase survival and physiological parameters in Alzheimer's disease models (3). Humanin is also believed to play neuroprotective roles in Huntington's deisease, prion disease and strokes (4). Humanin may playa role in various ot~er ailments including protection against oxidative stress, atherosclerotic plaque formation, heart attack and diabetes. (5, 6, 7, 8, 9).
The pan-Humanin selective antibodies were generated using a synthetic peptide corresponding to amino acid region 5-24 on human Humanin peptide. The Humanin antibodies are affinity purified over immobilized antigen based affinity chromatography. The purified immunoglobulins are prepared in stabilization buffer for long term storage. Antigenic blocking peptides, and western blot positive control in ready to use SDS-sample buffer are available. Antibodies can be conjugated to fluorophores and other secondary enzymes upon request at nominal cost. The pan-Humanin selective antibodies will label all Humanin isoforms except Humanin 9. Humanin 9-selective antibody is available for detection of only the Humanin 9 isoform.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
humanin-like 2
NCBI Official Synonym Full Names
MT-RNR2-like 2
NCBI Official Symbol
MTRNR2L2
NCBI Official Synonym Symbols
HN2
NCBI Protein Information
humanin-like 2
UniProt Protein Name
Humanin-like 2
Protein Family
UniProt Gene Name
MTRNR2L2
UniProt Synonym Gene Names
HN2
UniProt Entry Name
HMN2_HUMAN
Uniprot Description
MTRNR2L2: Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family.
Chromosomal Location of Human Ortholog: 5q14.1
Cellular Component: cytoplasm; extracellular region
Research Articles on MTRNR2L2
Similar Products
Product Notes
The MTRNR2L2 mtrnr2l2 (Catalog #AAA542854) is a Positive Control produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Humanin can be used in a range of immunoassay formats including, but not limited to, Western blot (WB). Western Blot: 1:500. Researchers should empirically determine the suitability of the MTRNR2L2 mtrnr2l2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Humanin, Positive Control" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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