Rabbit Synapsin 1 Polyclonal Antibody | anti-S9 antibody

Synapsin 1 (Phospho-S9) Polyclonal Antibody

Cat. Num. AAA3013958

• Gene Names: SYN1; SYNI; MRX50; SYN1a; SYN1b
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: ProA affinity purified
• Synonyms: Synapsin 1; Polyclonal Antibody; Synapsin 1 (Phospho-S9) Polyclonal Antibody; SYN1; Brain protein 4.1; SYN 1; SYN 1a; SYN 1b; SYN I; SYN1a; SYN1b; Synapsin I; Synapsin-1; Synapsin1; SynapsinI; SYNI; anti-S9 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Synapsin 1 (Phospho-S9) polyclonal antibody detects endogenous levels of Synapsin 1 protein only when phosphorylated at S9.
• Purity/Purification: ProA affinity purified
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 705

• Applicable Applications for anti-S9 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:1,000; IHC: 1:50-1:200
• Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser9 of human SynapsinI
• Preparation and Storage: Store at 4 degree C after thawing.; Aliquot store at -20 degree C or -80 degree C.; Avoid repeated freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti- phospho-Synapsin I (S9) antibody. Counter stained with hematoxylin.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti- phospho-Synapsin I (S9) antibody. Counter stained with hematoxylin.)

Related Product Information for anti-S9 antibody

Synapsins are synaptic vesicle-associated phosphoproteins that regulate synaptic vesicle exocytosis and may be involved in synaptogenesis. Evidence suggests that Synapsin I, Synapsin II and Synapsin IIIa are ATP-binding proteins that are regulated by Ca2+ and calmodulin binding. Ca2+ has been shown to stimulate ATP binding to Synapsin I, to have no effect on Synapsin II and to inhibit Synapsin III. Synapsin I and Synapsin II both undergo alternative splicing to produce two forms of each protein, Synapsin la and lb and Synapsin IIa and IIb, respectively. Synapsin III gives rise to at least three isoforms: Synapsin IIIa, IIIb and IIIc. Synapsin III plays unique roles both in early axon outgrowth and in the regulation of synaptic vesicle trafficking. In cultured mouse hippocampal neurons, Synapsin III is expressed early during development, with levels peaking seven days after plating and declining thereafter. Synapsin III is highly concentrated in growth cones.

NCBI and Uniprot Product Information

• NCBI GI #: 19924099
• NCBI GeneID: 6853
• NCBI Accession #: NP_008881.2
• NCBI GenBank Nucleotide #: NP_008881.2
• UniProt Accession #: P17600; O88935; P09951
• Molecular Weight: 77kDa
• NCBI Official Full Name: synapsin-1 isoform Ia
• NCBI Official Synonym Full Names: synapsin I
• NCBI Official Symbol: SYN1
• NCBI Official Synonym Symbols: SYNI; MRX50; SYN1a; SYN1b
• NCBI Protein Information: synapsin-1
• UniProt Protein Name: Synapsin-1
• Protein Family: Protein
• UniProt Gene Name: SYN1
• UniProt Entry Name: SYN1_HUMAN

NCBI Description

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

SYN1: neuronal phosphoprotein which associates with the cytoplasmic surface of synaptic vesicles and binds to the cytoskeleton. May function in the regulation of neurotransmitter release and of axonogenesis and synaptogenesis. Mutations may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Two differentially spiced isoforms have been reported.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: Golgi apparatus; synaptic vesicle; dendrite; cytosol; cell junction

Molecular Function: protein binding; transporter activity; actin binding; protein kinase binding; calcium-dependent protein binding; catalytic activity; ATP binding

Biological Process: synaptic transmission; metabolic process; neurotransmitter secretion; regulation of neurotransmitter secretion

Disease: Epilepsy, X-linked, With Variable Learning Disabilities And Behavior Disorders