Rabbit anti-Human CCR2 Polyclonal Antibody | anti-CCR2 antibody
CCR2 Antibody
ELISA: 1:10,000
Immunoprecipitation: 1:200
Western Blot: 1:500
Receptor for CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection.
NCBI and Uniprot Product Information
NCBI Description
mouse homolog is a chemokine receptor; involved in the immune response to viruses [RGD, Feb 2006]
Uniprot Description
CCR2: a seven transmembrane protein closely related to CCR1. Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. Transduces a signal by increasing the intracellular calcium ions level. Alternative co receptor with CD4 for HIV-1 infection. Two splice-variant isoforms have been described.
Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: cell soma; cell surface; cytoplasm; cytosol; dendrite; endosome; integral to membrane; integral to plasma membrane; perikaryon; perinuclear region of cytoplasm; plasma membrane
Molecular Function: C-C chemokine receptor activity; CCR2 chemokine receptor binding; chemokine receptor activity; protein homodimerization activity; protein kinase binding
Biological Process: aging; blood vessel remodeling; cellular calcium ion homeostasis; cellular defense response; cellular homeostasis; chemotaxis; cytokine and chemokine mediated signaling pathway; defense response to bacterium; dendritic cell chemotaxis; elevation of cytosolic calcium ion concentration; fat cell differentiation; forebrain development; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; inflammatory response to antigenic stimulus; JAK-STAT cascade; negative regulation of adenylate cyclase activity; negative regulation of angiogenesis; negative regulation of axon extension; negative regulation of cell migration; negative regulation of eosinophil degranulation; negative regulation of T-helper 2 type immune response; positive regulation of alpha-beta T cell proliferation; positive regulation of apoptosis by virus; positive regulation of fever; positive regulation of inflammatory response; positive regulation of interferon-gamma production; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-2 production; positive regulation of interleukin-6 production; positive regulation of neuron differentiation; positive regulation of T cell activation; positive regulation of T-helper 1 type immune response; positive regulation of tumor necrosis factor biosynthetic process; response to ionizing radiation; response to lipopolysaccharide; response to wounding
Research Articles on CCR2
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Product Notes
The CCR2 ccr2 (Catalog #AAA540147) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CCR2 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CCR2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB). Dot Blot: 1:10,000 ELISA: 1:10,000 Immunoprecipitation: 1:200 Western Blot: 1:500. Researchers should empirically determine the suitability of the CCR2 ccr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CCR2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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