Rabbit TMEM16A Polyclonal Antibody | anti-TMEM16A antibody
TMEM16A Antibody BIOTIN-Conjugated
Gene Names
Ano1; Tmem16a
Reactivity
Monkey, Mouse, Rat
Applications
ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
Synonyms
TMEM16A; Polyclonal Antibody; TMEM16A Antibody BIOTIN-Conjugated; ANO 1; Anoctamin 1; Anoctamin 1 calcium activated chloride channel; Ca2+ activated Cl- channel; Discovered on gastrointestinal stromal tumors protein 1; DOG 1; Membrane protein; Oral cancer overexpressed protein 2; ORAOV 2; TAOS2; Transmembrane protein 16A; Tumor-amplified and overexpressed sequence 2 antibody; anti-TMEM16A antibody
Host
Rabbit
Reactivity
Monkey, Mouse, Rat
Clonality
Polyclonal
Form/Format
BIOTIN-Conjugated
Concentration
0.50 ug/ul in antibody stabilization buffer (varies by lot)
Sequence Length
960
Applicable Applications for anti-TMEM16A antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:200
Western Blot: 1:500
ELISA: 1:10,000
Immunoprecipitation: 1:200
Western Blot: 1:500
Immunogen
Synthetic peptide taken within amino acid region on 70-120 on mouse Transmembrane Protein 16A.
Expression
Highly expressed in pulmonary bronchiole epithelial cells, pancreatic and submandibular gland acinar cells, kidney proximal tubule, all retinal cell layers, most sensory cells of dorsal root ganglia, Leydig cells and spermatocytes (at protein level). Expressed at high levels in the thyroid gland and gastrointestinal muscles.
Determinant
N-epitope
Molecular Function
Chloride channel, Developmental protein, Ion channel
Structure
Homodimer. Interacts with CFTR.
Subcellular Location
Cell membrane; Multi-pass membrane protein, Cytoplasm
Preparation and Storage
-20 degree C for long term storage
Related Product Information for anti-TMEM16A antibody
BIOTIN-Conjugated Transmembrane protein 16A Antibody N-epitope
Calcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
Calcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
110,489 Da
NCBI Official Full Name
Anoctamin-1
NCBI Official Synonym Full Names
anoctamin 1, calcium activated chloride channel
NCBI Official Symbol
Ano1
NCBI Official Synonym Symbols
Tmem16a
NCBI Protein Information
anoctamin-1
UniProt Protein Name
Anoctamin-1
UniProt Gene Name
Ano1
UniProt Synonym Gene Names
Tmem16a
UniProt Entry Name
ANO1_MOUSE
Uniprot Description
ANO1: Acts as a calcium-activated chloride channel. Required for normal tracheal development. Belongs to the anoctamin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Transporter, ion channel; Transporter; Membrane protein, multi-pass
Cellular Component: apical plasma membrane; cytoplasm; external side of plasma membrane; integral to membrane; membrane; plasma membrane
Molecular Function: calcium activated cation channel activity; chloride channel activity; intracellular calcium activated chloride channel activity; iodide transmembrane transporter activity; phospholipid scramblase activity; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; voltage-gated chloride channel activity
Biological Process: cation transport; chloride transport; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); iodide transport; ion transport; multicellular organismal development; regulation of membrane potential; transport
