M-CSF active protein
M-CSF protein
Applications
User optimized
Purity
> 98% pure
Synonyms
M-CSF; M-CSF protein; CSF-1 protein; MGI-IM protein; Macrophage Colony Stimulating Factor protein; M-CSF active protein
Host
Human
Purity/Purification
> 98% pure
Form/Format
Lyophilized from Na3PO4 buffer, pH 8.0, with 75mM NaCl. Reconstitute with distilled water to a concentration of 0.1 to 0.5mg/ml.
Sequence
Region of M-CSF protein corresponding to amino acids MEEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVD QEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQ LQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKN VFNETKNLLD KDWNIFSKNC NNSFAECSSQ GHERQSEGS.
Sequence Length
153
Applicable Applications for M-CSF active protein
User optimized
Protein Type
Recombinant
Biological Significance
M-CSF is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. The human is reactive in Mouse systems, but the Mouse molecule exhibits no activity on human cells.
Bioactivity
The ED50 was determined by the dose-dependent stimulation of the proliferation of Mouse M-NSF-60 cells 1 ng/ml, corresponding to a specific activity of approximately 1 x 10^6 units/mg.
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Expression System
E Coli
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Related Product Information for M-CSF active protein
Purified recombinant Human M-CSF protein
Product Categories/Family for M-CSF active protein
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
36.8 kDa
NCBI Official Full Name
macrophage colony-stimulating factor, M-CSF {N-terminal}
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Product Notes
The M-CSF (Catalog #AAA538234) is an Active Protein produced from Human and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's M-CSF can be used in a range of immunoassay formats including, but not limited to, User optimized. Researchers should empirically determine the suitability of the M-CSF for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Region of M-CSF protein correspond ing to amino acids MEEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVD QEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQ LQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKN VFNETKNLLD KDWNIFSKNC NNSFAECSSQ GHERQSEGS. It is sometimes possible for the material contained within the vial of "M-CSF, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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