Wnt1 active protein
Wnt1 protein
Purity
> 98% by SDS-PAGE gel and HPLC analysis
Synonyms
Wnt1; Wnt1 protein; Wnt 1 protein; Wnt-1 protein; Wnt 1; Wnt-1; INT-1 protein; Wnt1 active protein
Host
E. Coli
Purity/Purification
> 98% by SDS-PAGE gel and HPLC analysis
Form/Format
Sterile filtered through a 0.2 micron filter. Lyophilzed with no additives. Centrifuge vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0mg/ml. Do not vortex.
Concentration
10ug per vial; lyophilized (varies by lot)
Sequence
Region of Wnt1 protein corresponding to amino acids: ANSSGRWWGI VNVASSTNLL TDSKSLQLVL EPSLQLLSRK QRRLIRQNPG ILHSVSGGLQ SAVRECKWQF RNRRWNCPTA PGPHLFGKIV NRGCRETAFI FAITSAGVTH SVARSCSEGS IESCTCDYRR RGPGGPDWHW GGCSDNIDFG RLFGREFVDS GEKGRDLRFL MNLHNNEAGR TTVFSEMRQE CKCHGMSGSC TVRTCWMRLP TLRAVGDVLR DRFDGASRVL YGNRGSNRAS RAELLRLEPE DPAHKPPSPH DLVYFEKSPN FCTYSGRLGT AGTAGRACNS SSPALDGCEL LCCGRGHRTR TQRVTERCNC TFHWCCHVSC RNCTHTRVLH ECL.
Grade
Recombinant human protein
Contaminants
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Biohazard
Not for human use. Use normal laboratory precautions when handling reagent. For research purposes only.
Biological Significance
Wnt-1 is a secreted protein that signals through the Frizzled family of cell surface receptors and is required for normal embryonic development. Wnt-1 activation induces a complex signaling cascade that ultimately leads to the increased expression of over fifty genes. An important component of Wnt-1 signaling is the stabilization, and resulting accumulation, of the intracellular signaling protein, beta-catenin. Wnt signaling induces and maintains the transformed phenotype and, in certain embryonic cell lines, supports self renewal in the absence of significant differentiation. Elevated levels of Wnt proteins are associated with tumorigenesis and are present in numerous human breast cancers.
Preparation and Storage
Ships on blue ice. Upon receipt store at 4°C short term, -20°C long term.
Related Product Information for Wnt1 active protein
Purified recombinant Human Wnt1 protein
Product Categories/Family for Wnt1 active protein
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
38.4 kDa
NCBI Official Full Name
Wnt1, partial
UniProt Protein Name
Protein Wnt
Protein Family
UniProt Gene Name
Wnt1
UniProt Entry Name
C4P689_OCTBM
Uniprot Description
Ligand for members of the frizzled family of seven transmembrane receptors.
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Product Notes
The Wnt1 wnt1 (Catalog #AAA538123) is an Active Protein produced from E. Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Region of Wnt1 protein correspond ing to amino acids: ANSSGRWWGI VNVASSTNLL TDSKSLQLVL EPSLQLLSRK QRRLIRQNPG ILHSVSGGLQ SAVRECKWQF RNRRWNCPTA PGPHLFGKIV NRGCRETAFI FAITSAGVTH SVARSCSEGS IESCTCDYRR RGPGGPDWHW GGCSDNIDFG RLFGREFVDS GEKGRDLRFL MNLHNNEAGR TTVFSEMRQE CKCHGMSGSC TVRTCWMRLP TLRAVGDVLR DRFDGASRVL YGNRGSNRAS RAELLRLEPE DPAHKPPSPH DLVYFEKSPN FCTYSGRLGT AGTAGRACNS SSPALDGCEL LCCGRGHRTR TQRVTERCNC TFHWCCHVSC RNCTHTRVLH ECL. It is sometimes possible for the material contained within the vial of "Wnt1, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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