VEGFR1 recombinant protein

VEGFR1 protein

Cat. Num. AAA537192

• Gene Names: FLT1; FLT; FLT-1; VEGFR1; VEGFR-1
• Applications: User optimized
• Purity: > 90% pure
• Synonyms: VEGFR1; VEGFR1 protein; FLT-1 protein; Vascular Endothelial Growth Factor Receptor 1 protein; VEGF-R1 protein; D1-5 protein; FLT1 protein; VEGFR1 recombinant protein

• Host: Human
• Purity/Purification: > 90% pure
• Form/Format: Supplied as a lyophilized powder. Reconstitute in PBS or sterile water to a concentration of > 100 ng/ml.
• Sequence Length: 541

• Applicable Applications for VEGFR1 recombinant protein: User optimized
• Protein Type: Recombinant
• Biological Significance: Human soluble Vascular Endothelial Growth Factor Receptor-1 consists of the first 6 extracellular domains (Met1-His688) containing the unique 31 amino acids residues at the C-terminus. Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (kDaR/Flk-1), and VEGFR-3 (Flt-4).
• Endotoxin Levels: <0.1 ng per mg of VEGFR-1
• Expression System: Sf-9 insect cells
• Preparation and Storage: Store at -70 degree C until reconstitution. Following reconstitution product should be aliquoted and frozen at -20 degree C. Avoid repeated freeze/thaw cycles.

Related Product Information for VEGFR1 recombinant protein

Purified recombinant Human VEGFR1 protein

Product Categories/Family for VEGFR1 recombinant protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 229892302
• NCBI GeneID: 2321
• NCBI Accession #: NP_001153503.1
• NCBI GenBank Nucleotide #: NM_001160031.1
• UniProt Accession #: P17948; O60722; A3E342; A3E344; A8KA71; B0LPF1; B2BF46; B2BF47; B2BF48; B3FR89; B5A923; F5H5L6
• Molecular Weight: 70 kDa
• NCBI Official Full Name: vascular endothelial growth factor receptor 1 isoform 4
• NCBI Official Synonym Full Names: fms-related tyrosine kinase 1
• NCBI Official Symbol: FLT1
• NCBI Official Synonym Symbols: FLT; FLT-1; VEGFR1; VEGFR-1
• NCBI Protein Information: vascular endothelial growth factor receptor 1
• UniProt Protein Name: Vascular endothelial growth factor receptor 1
• UniProt Gene Name: FLT1
• UniProt Synonym Gene Names: FLT; FRT; VEGFR1; VEGFR-1; FLT-1; FLT
• UniProt Entry Name: VGFR1_HUMAN

NCBI Description

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]

Uniprot Description

VEGFR1: a receptor tyrosine kinase of the VEGFR family. Receptor for VEGF, VEGFB and PGF. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Two splice variant isoforms have been described. Isoform SFlt1 may have an inhibitory role in angiogenesis.

Protein type: Protein kinase, TK; Protein kinase, tyrosine (receptor); Kinase, protein; Membrane protein, integral; EC 2.7.10.1; TK group; VEGFR family

Chromosomal Location of Human Ortholog: 13q12

Cellular Component: extracellular space; focal adhesion; integral to plasma membrane; plasma membrane; receptor complex; endosome

Molecular Function: identical protein binding; vascular endothelial growth factor receptor activity; protein binding; growth factor binding; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: cell migration; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of phosphoinositide 3-kinase cascade; patterning of blood vessels; monocyte chemotaxis; positive regulation of MAP kinase activity; positive regulation of angiogenesis; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; blood vessel morphogenesis; embryonic morphogenesis; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration