CTGFL active protein
CTGFL protein
Applications
User optimized
Purity
> 95% pure
Synonyms
CTGFL; CTGFL protein; WISP2 protein; CCN5 protein; CT-58 protein; Connective Tissue Growth Factor-Like protein protein; CTGFL active protein
Host
Human
Purity/Purification
> 95% pure
Form/Format
Supplied lyophilized with no additives. Reconstitute in water to a concentration of 0.1- 1.0 mg/ml. Do not raise to neutral pH.
Sequence
Region of CTGFL protein corresponding to amino acids MQLCPTPCTC PWPPPRCPLG VPLVLDGCGC CRVCARRLGE PCDQLHVCDA SQGLVCQPGA GPGGRGALCL LAEDDSSCEV NGRLYREGET FQPHCSIRCR CEDGGFTCVP LCSEDVRLPS WDCPHPRRVE VLGKCCPEWV CGQGGGLGTQ PLPAQGPQFS GLVSSLPPGV PCPEWSTAWG PCSTTCGLGM ATRVSNQNRF CRLETQRRLC LSRPCPPSRG RSPQNSAF.
Sequence Length
251
Applicable Applications for CTGFL active protein
User optimized
Protein Type
Recombinant
Biological Significance
CTGFL/WISP-2 is a 24.3 kDa protein that belongs to the CCN family of cysteine rich regulatory proteins. Members of this family stimulate mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest, and migration of multiple cell types. The protein is expressed in primary osteoblasts, fibroblasts, ovary, testes, and heart. In addition to promoting adhesion of osteoblasts, CTGFL/WISP-2 inhibits osteocalcin production, as well as binding of fibrinogen to integrin receptors.
Bioactivity
The ED50 was determined by its ability to inhibit IGF-II induced proliferation of MCF-7 is between 10-20 ng/ml in the presence of 15 ng/ml of human IGF-II.
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Expression System
E Coli
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Related Product Information for CTGFL active protein
Purified recombinant Human CTGFL protein
Product Categories/Family for CTGFL active protein
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
24.3 kDa
NCBI Official Full Name
connective tissue growth factor-like protein
UniProt Protein Name
WNT1-inducible-signaling pathway protein 2
UniProt Gene Name
Wisp2
UniProt Synonym Gene Names
Ccn5; Ctgfl; WISP-2; CTGF-L
UniProt Entry Name
WISP2_MOUSE
Uniprot Description
WISP2: May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production. Belongs to the CCN family.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: proteinaceous extracellular matrix; extracellular space; cell surface; cytoplasm; plasma membrane; extracellular region
Molecular Function: heparin binding; integrin binding; insulin-like growth factor binding; growth factor activity
Biological Process: negative regulation of cell proliferation; cell-cell signaling; regulation of cell growth; cell adhesion; signal transduction
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Product Notes
The CTGFL wisp2 (Catalog #AAA536553) is an Active Protein produced from Human and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's CTGFL can be used in a range of immunoassay formats including, but not limited to, User optimized. Researchers should empirically determine the suitability of the CTGFL wisp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Region of CTGFL protein correspond ing to amino acids MQLCPTPCTC PWPPPRCPLG VPLVLDGCGC CRVCARRLGE PCDQLHVCDA SQGLVCQPGA GPGGRGALCL LAEDDSSCEV NGRLYREGET FQPHCSIRCR CEDGGFTCVP LCSEDVRLPS WDCPHPRRVE VLGKCCPEWV CGQGGGLGTQ PLPAQGPQFS GLVSSLPPGV PCPEWSTAWG PCSTTCGLGM ATRVSNQNRF CRLETQRRLC LSRPCPPSRG RSPQNSAF. It is sometimes possible for the material contained within the vial of "CTGFL, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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