Rabbit anti-Porcine Neuromedin U Polyclonal Antibody | anti-NMU antibody

Neuromedin U antibody

Cat. Num. AAA535285

• Reactivity: Porcine
• Applications: Immunofluorescence, Immunohistochemistry
• Purity: Whole antiserum
• Synonyms: Neuromedin U; Polyclonal Antibody; Neuromedin U antibody; Polyclonal Neuromedin U; Anti-Neuromedin U; anti-NMU antibody

• Host: Rabbit
• Reactivity: Porcine
• Clonality: Polyclonal
• Isotype: IgG1
• Specificity: Porcine neuromedin U
• Purity/Purification: Whole antiserum
• Form/Format: Supplied as a lyophilized powder. Dissolve the antiserum in 50 - 100 ul distilled water, and dilute further in 0.1M PBS with 1% BSA and 0.1% NaN3.
• Concentration: 50ul, lyophilized (varies by lot)
• Sequence Length: 174

• Applicable Applications for anti-NMU antibody: Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin/Paraffin
• Application Notes: IF-FITC: 1:1,000-1:1,500
• Biological Significance: Neuromedin U is a neuropeptide found in the brain of humans and other mammals, which has a number of diverse functions including contraction of smooth muscle, regulation of blood pressure, pain perception, appetite, bone growth, and hormone release. It was first isolated from the spinal cord in 1985, and named after its ability to cause smooth muscle contraction in the uterus.
• Cross-Reactivity: Chicken, rat
• Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
• Immunogen: Neuromedin U antibody was raised in rabbit using synthetic neuromedin U-8, porcine sequence, conjugated to BSA as the immunogen.
• Preparation and Storage: Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-NMU antibody

Rabbit polyclonal Neuromedin U antibody

Product Categories/Family for anti-NMU antibody

Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 609013
• NCBI GeneID: 10874
• UniProt Accession #: P48645
• Molecular Weight: 19,741 Da
• NCBI Official Full Name: neuromedin U
• NCBI Official Synonym Full Names: neuromedin U
• NCBI Official Symbol: NMU
• NCBI Protein Information: neuromedin-U
• UniProt Protein Name: Neuromedin-U
• Protein Family: Neuromedin
• UniProt Gene Name: NMU
• UniProt Synonym Gene Names: NmU-25
• UniProt Entry Name: NMU_HUMAN

NCBI Description

This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015]

Uniprot Description

NMU: Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder. Belongs to the NmU family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q12

Cellular Component: extracellular region; terminal button

Molecular Function: neuromedin U receptor binding; receptor binding

Biological Process: regulation of smooth muscle contraction; gastric acid secretion; G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway; eating behavior; photoperiodism; digestion; positive regulation of hormone secretion; positive regulation of smooth muscle contraction; sensory perception of pain; signal transduction; positive regulation of synaptic transmission