Mouse anti-Human BMP7 BMP7 Monoclonal Antibody | anti-BMP7 antibody

BMP7 antibody

Cat. Num. AAA532118

• Gene Names: BMP7; OP-1
• Reactivity: Human BMP7
• Applications: ELISA, Western Blot
• Synonyms: BMP7; Monoclonal Antibody; BMP7 antibody; Monoclonal BMP7; Anti-BMP7; BMP 7; BMP-7; 7; Bone Morphogenetic; OP-1; anti-BMP7 antibody

• Host: Mouse
• Reactivity: Human BMP7
• Clonality: Monoclonal
• Isotype: IgG1 kappa
• Clone Number: M912263
• Specificity: Human BMP7
• Form/Format: Lyophilized from PBS.
• Concentration: 500ug, lyophilized (varies by lot)
• Sequence Length: 139

• Applicable Applications for anti-BMP7 antibody: ELISA (EIA), Inhibition, Western Blot (WB)
• Application Notes: ELISA: 2-4 ug/ml
• Biological Significance: TGF beta family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. BMP-7, also known as osteogenic protein-1 or OP-1, is a potent bone inducing agent, which in the presence of appropriate osteoconductive carrier (e.g. collagen sponge or synthetic hydroxyapatite) can be used in the treatment of bone defects. A bone-graft substitute, called OP-1TM implant, made of recombinant human BMP-7 associated with bovine bone-derived collagen, has recently been approved by the FDA as a device for treating critical-size bone fractures.
• Immunogen: BMP7 antibody was raised in mouse using recombinant human BMP-7/OP-1 as the immunogen.
• Preparation and Storage: Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.

Related Product Information for anti-BMP7 antibody

Mouse monoclonal BMP7 antibody

Product Categories/Family for anti-BMP7 antibody

Differentiation & Development

NCBI and Uniprot Product Information

• NCBI GI #: 12003264
• NCBI GeneID: 655
• UniProt Accession #: Q9H2W7; P18075
• Molecular Weight: 28.8 kDa (predicted detection band MW)
• NCBI Official Full Name: bone morphogenetic protein 7, partial
• NCBI Official Synonym Full Names: bone morphogenetic protein 7
• NCBI Official Symbol: BMP7
• NCBI Official Synonym Symbols: OP-1
• NCBI Protein Information: bone morphogenetic protein 7
• UniProt Protein Name: Bone morphogenetic protein 7
• Protein Family: Bone morphogenetic protein
• UniProt Gene Name: BMP7
• UniProt Entry Name: Q9H2W7_HUMAN

NCBI Description

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq, Jul 2008]

Uniprot Description

BMP7: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1. Expressed in the kidney and bladder. Lower levels seen in the brain. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20q13

Cellular Component: extracellular matrix; extracellular space; extracellular region

Molecular Function: heparin binding; protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: negative regulation of MAP kinase activity; response to peptide hormone stimulus; axon guidance; extracellular matrix organization and biogenesis; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of NF-kappaB import into nucleus; embryonic pattern specification; response to estradiol stimulus; negative regulation of cell cycle; BMP signaling pathway; regulation of apoptosis; response to vitamin D; epithelial cell differentiation; ureteric bud development; dendrite development; mesonephros development; skeletal development; embryonic limb morphogenesis; ossification; positive regulation of heterotypic cell-cell adhesion; positive regulation of bone mineralization; odontogenesis of dentine-containing teeth; positive regulation of osteoblast differentiation; negative regulation of neuron differentiation; mesenchymal cell differentiation; mesoderm formation; branching morphogenesis of a tube; inhibition of NF-kappaB transcription factor; cartilage development; negative regulation of mitosis; epithelial to mesenchymal transition; negative regulation of Notch signaling pathway; negative regulation of phosphorylation; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; embryonic camera-type eye morphogenesis; negative regulation of transcription, DNA-dependent; metanephros development; neurite morphogenesis; growth