Mouse Calcineurin B Monoclonal Antibody | anti-PPP3R1 antibody
Calcineurin B antibody
Reactivity
Human, Mouse, Rat
Applications
Western Blot
Synonyms
Calcineurin B; Monoclonal Antibody; Calcineurin B antibody; Monoclonal Calcineurin B; Anti-Calcineurin B; anti-PPP3R1 antibody
Host
Mouse
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
323417
Specificity
Human calcineurin B
Form/Format
Lyophilized from a 0.2 u filtered solution in PBS with 5% trehalose. Reconstitute with sterile PBS.
Sequence Length
170
Applicable Applications for anti-PPP3R1 antibody
Western Blot (WB)
Application Notes
WB: 0.5 ug/ml
Biological Significance
Calcineurin (CN) is a protein phosphatase also known as protein phosphatase 3, PPP3CA, and formerly known as protein phosphatase 2B (PP2B). It activates the T cells of the immune system and can be blocked by drugs. Calcineurin activates NFATc (Nuclear Factor of Activated T cell, cytoplasmic), a transcription factor, by dephosphorylating it. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of T cell response. Calcineurin is the target of a class of drugs called calcineurin inhibitors, which includes ciclosporin, pimecrolimus and tacrolimus.
Cross-Reactivity
Human, mouse, rat
Immunogen
Calcineurin B antibody was raised in mouse using E Coli-derived recombinant human calcineurin B as the immunogen.
Preparation and Storage
Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
Related Product Information for anti-PPP3R1 antibody
Mouse monoclonal Calcineurin B antibody
Product Categories/Family for anti-PPP3R1 antibody
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
19,300 Da
NCBI Official Full Name
calcineurin B
UniProt Protein Name
Calcineurin subunit B type 1
Protein Family
UniProt Gene Name
PPP3R1
UniProt Synonym Gene Names
CNA2; CNB
UniProt Entry Name
CANB1_HUMAN
Uniprot Description
PPP3R1: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. Belongs to the calcineurin regulatory subunit family.
Protein type: Protein phosphatase, regulatory subunit; Motility/polarity/chemotaxis; Apoptosis; Cell development/differentiation
Chromosomal Location of Human Ortholog: 2p15
Cellular Component: nucleoplasm; calcineurin complex; cytosol; sarcolemma
Molecular Function: calmodulin binding; protein domain specific binding; protein binding; calcium-dependent protein serine/threonine phosphatase activity; calcium ion binding
Biological Process: calcineurin-NFAT signaling pathway; positive regulation of NFAT protein import into nucleus; dephosphorylation; apoptosis; innate immune response; positive regulation of transcription from RNA polymerase II promoter
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Product Notes
The Calcineurin B ppp3r1 (Catalog #AAA531795) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Calcineurin B antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Calcineurin B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 0.5 ug/ml. Researchers should empirically determine the suitability of the Calcineurin B ppp3r1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Calcineurin B, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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