Rabbit anti-Mouse EGFR Polyclonal Antibody | anti-EGFR antibody

EGFR antibody

• Gene Names: Egfr; C-erb; c-erbB; CG10079; D-Egf; d-egf-r; D-EGFR; degfr; dEgfr; dEGFr; dEGFR; Degfr; DEgfr; DEGFR; dEGFR1; der; Der; DER; DER flb; DER/EGFR; DER/top; DER/torpedo; DER1; DmelCG10079; DmHD-33; EC2-4; EFG-R; Egf; Egf-r; EGF-R; egfr; EgfR; EGfr; EGFr; EGFR; EK2
• Reactivity: Mouse
• Applications: Immunoprecipitation, Western Blot
• Synonyms: EGFR; Polyclonal Antibody; EGFR antibody; Rabbit polyclonal EGFR antibody; Polyclonal EGFR antibody; Anti-EGFR antibody; Epidermal growth factor receptor antibody; anti-EGFR antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Specificity: The antibody recognizes the EGFR of human and mouse origins. Reactivity to other species has not been tested.
• Form/Format: Supplied in PBS buffer containing 30% glycerol,0.5% BSA and 0.01% thimerosal.
• Sequence Length: 1426

• Applicable Applications for anti-EGFR antibody: Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: WB: 1:1000-1:2500
• Immunogen: EGFR antibody was raised in Rabbit using synthetic peptide of human EGFR as the immunogen.
• Cross-Reactivity: Human, Mouse
• Preparation and Storage: Store at-20 degree C. For long-term storage, aliquot and freeze at-70 degree C.; Avoid repeated freeze/thaw cycles.

Related Product Information for anti-EGFR antibody

The epidermal growth factor receptor (EGF R) subfamily of receptor tyrosine kinases comprises four members: EGF R (also known as HER1, ErbB1 or ErbB), ErbB2 (Neu, HER 2), ErbB3 (HER 3), and ErbB4 (HER 4). All family members are type I transmembrane glycoprotein that has an extracellular domain which contains two cysteine rich domains separated by a spacer region that is involved in ligand binding, and a cytoplasmic domain which has a membrane proximal tyrosine kinase domain and a C terminal tail with multiple tyrosine autophosphorylation sites. The human EGF R gene encodes a 1210 amino acid (aa) residue precursor with a 24 aa putative signal peptide, a 621 aa extracellular domain, a 23 aa transmembrane domain, and a 542 aa cytoplasmic domain. EGF R has been shown to bind a subset of the EGF family ligands, including EGF, amphiregulin, TGF, betacellulin, epiregulin, heparin binding EGF and neuregulin 2 in the absence of a coreceptor. Ligand binding induces EGF R homodimerization as well as heterdimerization with ErbB2, resulting in kinase activation, tyrosine phosphorylation and cell signaling.

Product Categories/Family for anti-EGFR antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 17136536
• NCBI GeneID: 37455
• NCBI Accession #: NP_476759.1
• NCBI GenBank Nucleotide #: NM_057411.4
• UniProt Accession #: P04412; O18370; O61601; P81868; Q9W2G0
• Molecular Weight: 153,700 Da
• NCBI Official Full Name: epidermal growth factor receptor, isoform B
• NCBI Official Synonym Full Names: Epidermal growth factor receptor
• NCBI Official Symbol: Egfr
• NCBI Official Synonym Symbols: C-erb; c-erbB; CG10079; D-Egf; d-egf-r; D-EGFR; degfr; dEgfr; dEGFr; dEGFR; Degfr; DEgfr; DEGFR; dEGFR1; der; Der; DER; DER flb; DER/EGFR; DER/top; DER/torpedo; DER1; DmelCG10079; DmHD-33; EC2-4; EFG-R; Egf; Egf-r; EGF-R; egfr; EgfR; EGfr; EGFr; EGFR; EK2
• NCBI Protein Information: epidermal growth factor receptor
• UniProt Protein Name: Epidermal growth factor receptor
• Protein Family: Epidermal growth factor receptor
• UniProt Gene Name: Egfr
• UniProt Synonym Gene Names: c-erbB; DER; top; Egfr

Uniprot Description

Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production of cuticle. Required for embryonic epithelial tissue repair.