Bordetella pertussis toxin Native Protein
Purified Native Bordetella pertussis toxin protein
Purity
> 98% by SDS-PAGE.
Synonyms
Bordetella pertussis toxin; Purified Native Bordetella pertussis toxin protein; Bordetella pertussis toxin antigen; Bordetella pertussis protein; B pertussis toxin protein; Pertussis toxin protein; PT protein; Bordetella pertussis toxin native protein
Host
B.pertussis strain NC10739/ACTC 9797
Purity/Purification
> 98% by SDS-PAGE.
Form/Format
Liquid in 50mM Sodium Phosphate and 500 mM Sodium Chloride, pH 7.2
Concentration
0.25 mg/ml (varies by lot)
Species
Viral
Protein Type
Native
Biohazard
Use standard laboratory precautions when handling this material.
Biological significance
Pertussis toxin (PT) is a protein-based AB5-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough. PT is involved in the colonization of the respiratory tract and the establishment of infection. Research suggests PT may have a therapeutic role in treating a number of common human ailments, including hypertension, viral inhibition, and autoimmune inhibition.
Implications in Disease
Pertussis (or whooping cough) is an infection of the respiratory system characterized by a “whooping” sound when the person breathes in. B. pertussis has the ability to inhibit the function of the host's immune system. The toxin, known as pertussis toxin (or PTx), inhibits G protein coupling that regulates an adenylate cyclase-mediated conversion of ATP to cyclic AMP. The end result is phagocytes convert too much ATP to cyclic AMP, which can cause disturbances in cellular signaling mechanisms, and prevent phagocytes from correctly responding to an infection. The infection occurs mostly in children under the age of one when they are unimmunized, or children with faded immunity, normally around the ages 11 through 18. The signs and symptoms are similar to a common cold: runny nose, sneezing, mild cough, and low-grade fever. The patient becomes most contagious during the catarrhal stage of infection, normally two weeks after the coughing begins.
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store at 4°C for short term, -20°C to -80°C for long term. Avoid repeat freeze/thaws.
Product Categories/Family for Bordetella pertussis toxin native protein
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Product Notes
The Bordetella pertussis toxin (Catalog #AAA5308269) is a Native Protein produced from B.pertussis strain NC10739/ACTC 9797 and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Bordetella pertussis toxin, Native Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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