SDS-PAGE
(SDS-PAGE analysis of Zika virus NS1 protein (30-1936)Coomassie stained SDS-PAGE gel showing Zika virus NS1 protein migrating at approximately 50 kDa.)
Zika virus NS1 Recombinant Protein
Zika virus NS1 protein
Applications
ELISA, Lateral Flow
Purity
> 90% pure by SDS-PAGE, Single band visible.
Synonyms
Zika virus NS1; Zika virus NS1 protein; Zika protein; Zika virus antigen; recombinant Zika protein; recombinant Zika antigen; Zika NS1 protein; Zika virus NS1 antigen; recombinant Zika NS1 protein; recombinant Zika NS1 antigen; Zika virus Non-Structural protein 1; Zika Non Structural protein 1; ZIKV protein; ZIKV antigen; ZIKV NS1; Zika virus NS1 recombinant protein
Purity/Purification
> 90% pure by SDS-PAGE, Single band visible.
Form/Format
Liquid in PBS buffer, pH7.4, with 0.05% Sodium Azide.
Concentration
4.5 mg/ml by Bradford Assay (varies by lot)
Applicable Applications for Zika virus NS1 recombinant protein
ELISA (EIA), Lateral Flow
Expression System
Insect cells
Source
Baculovirus derived recombinant protein consisting of amino acids 792-1144 expressed in an insect cell line.
Grade
Recombinant
Species
Viral
Residues
Zika virus NS1 comprising amino acids 792-1144.
Biohazard
Use standard laboratory precautions when handling this material.
Biological Significance
Zika virus (ZIKV), a Flaviviridae family member transmitted to humans by mosquitoes of the genus Aedes, was first isolated in Africa in 1947. It has been found to commonly circulate in tropical regions in Africa and Asia. As a member of the Flaviviridae family, ZIKV has a single positive sense RNA genome, which is initially translated as a single polyprotein which is then cleaved post-translationally into three structural proteins (C, PrM or M, and E) and seven nonstructural (NS) proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5). NS1 is required for viral replication inside cells and is also secreted into the extracellular space as a hexameric lipoprotein particle, which is involved in immune evasion and pathogenesis by interacting with components from both the innate and adaptive immune systems.
Implications in Disease
There is growing evidence that Zika virus infections may be linked to fetal and newborn microcephaly and serious neurological complications, such as Guillain Barré syndrome. NS1 is the major antigenic marker for viral infection. To date, no clinically approved vaccines or therapeutics are available to prevent and control of Zika virus infection.
Sequence Information
Zika NS1 is a highly conserved region of the virus.
Post-Translational Modifications
Post translationally, NS1 is glycosylated and associates with lipids forming a homodimer inside the cells. It is necessary for viral replication and late in infection.
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Ships with Dry Ice. Upon receipt store at or below -20 degree C. Avoid repeated freeze thaw cycles.
SDS-PAGE
(SDS-PAGE analysis of Zika virus NS1 protein (30-1936)Coomassie stained SDS-PAGE gel showing Zika virus NS1 protein migrating at approximately 50 kDa.)
SDS-PAGE
(SDS-PAGE analysis of Zika virus NS1 protein (30-1936)Coomassie stained SDS-PAGE gel showing Zika virus NS1 protein migrating at approximately 50 kDa.)
Related Product Information for Zika virus NS1 recombinant protein
Recombinant Zika virus NS1 protein
Similar Products
Product Notes
The Zika virus NS1 (Catalog #AAA5304719) is a Recombinant Protein and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Zika virus NS1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Lateral Flow. Researchers should empirically determine the suitability of the Zika virus NS1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Zika virus NS1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
