Specific Activity
(Binding ability measured in a functional ELISA. CD147 (22-205) protein (His tag) can bind to immobilized 2019-nCoV spike protein RBD (Fc-tag) ( MBS515721 ).)
CD147 Active Protein
CD147 (22-205) Protein
Synonyms
CD147; CD147 (22-205) Protein; Basigin; EMMPRIN; CD147 active protein
Host
CHO Cells
Form/Format
Recombinant protein stored in 50mM sodium phosphate, pH7.5, 300mM NaCl, 150mM imidazole
Species
Human
Tag
HIS
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at the recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Specific Activity
(Binding ability measured in a functional ELISA. CD147 (22-205) protein (His tag) can bind to immobilized 2019-nCoV spike protein RBD (Fc-tag) ( MBS515721 ).)
Specific Activity
(Binding ability measured in a functional ELISA. CD147 (22-205) protein (His tag) can bind to immobilized 2019-nCoV spike protein RBD (Fc-tag) ( MBS515721 ).)
Purity Data
(The purity of CD147 (22-205) was determined to be >90% by densitometry. Approx. MW 30-36 kDa.)
Purity Data
(The purity of CD147 (22-205) was determined to be >90% by densitometry. Approx. MW 30-36 kDa.)
Related Product Information for CD147 active protein
Recombinant human CD147 (22-205) protein was expressed in CHO cells using a C-terminal His-tag. The gene accession number is NM_198589
Overview: CD147 is a highly glycosylated transmembrane protein that acts as the main upstream stimulator of matrix metalloproteinases (MMPs) (1). It has been reported to bind viral Spike protein of SARS-Co-2, thereby playing a functional role in mediating the viral invasion of the host cell. It also acts as an RBC receptor for Plasmodium falciparum, a Malarial protozoan (2). In addition, expression level of CD147 is increased in tumor tissue, inflammation, and pathogenically infected cells. Therefore, CD147 receptor blocking drugs may provide novel therapeutic strategies against viral invasions, such as 2019-nCoV (3).
Overview: CD147 is a highly glycosylated transmembrane protein that acts as the main upstream stimulator of matrix metalloproteinases (MMPs) (1). It has been reported to bind viral Spike protein of SARS-Co-2, thereby playing a functional role in mediating the viral invasion of the host cell. It also acts as an RBC receptor for Plasmodium falciparum, a Malarial protozoan (2). In addition, expression level of CD147 is increased in tumor tissue, inflammation, and pathogenically infected cells. Therefore, CD147 receptor blocking drugs may provide novel therapeutic strategies against viral invasions, such as 2019-nCoV (3).
Product Categories/Family for CD147 active protein
References
1. Kong LM, et al: A regulatory loop involving miR-22, Sp1, and c-Myc modulates CD147 expression in breast cancer invasion and metastasis. Cancer Research. 2014, 74(14):3764-78.
2. Wang K, et al SARS-CoV-2 invades host cells via a novel route: CD147-spike protein. BioRxiv. 2020 doi: https://doi.org/10.1101/2020.03.14.988345
3. Ulrich H, et al: CD147 as a target for COVID-19 treatment: Suggested effects of azithromycin and stem cell engagement.
2. Wang K, et al SARS-CoV-2 invades host cells via a novel route: CD147-spike protein. BioRxiv. 2020 doi: https://doi.org/10.1101/2020.03.14.988345
3. Ulrich H, et al: CD147 as a target for COVID-19 treatment: Suggested effects of azithromycin and stem cell engagement.
NCBI and Uniprot Product Information
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Product Notes
The CD147 (Catalog #AAA515773) is an Active Protein produced from CHO Cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CD147, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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