Testing Data
PCTK1 recombinant protein
PCTK1 (CDK16)/CyclinY, Active
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Testing Data
Testing Data
Testing Data #2
Testing Data #2
Scientific Background: PCTK1 or PCTAIRE PROTEIN KINASE 1 belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. PCTK1 plays a role in signal transduction cascades in terminally differentiated cells, in exocytosis, and in transport of secretory cargo from the endoplasmic reticulum (1). PCTK1 is ubiquitously expressed with the highest levels detected in the brain and testis. PCTK1 also contained the gene coding for ubiquitin-activating enzyme UBE1 that previously shown to mapped to Xp11.3 (2).
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]
Uniprot Description
CDK16: an atypical member of the cyclin-dependent kinase (CDK) family. Activated via binding phosphorylated cyclin Y complexed with 14-3-3 zeta, theta, or eta. Plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development. Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Three isoforms of the human protein may be generated via alternative splicing.
Protein type: CDK family; CDK/TAIRE subfamily; CMGC group; Cell cycle regulation; EC 2.7.11.22; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); TAIRE subfamily
Chromosomal Location of Human Ortholog: Xp11.3
Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; microtubule cytoskeleton; nucleus; plasma membrane; synaptic vesicle
Molecular Function: cyclin-dependent protein kinase activity; protein binding; protein serine/threonine kinase activity
Biological Process: exocytosis; growth hormone secretion; neurite development; spermatogenesis
Research Articles on PCTK1
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Product Notes
The PCTK1 cdk16 (Catalog #AAA515565) is a Recombinant Protein produced from Sf9 insect cells using baculovirus and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is PCTK1 (CDK16) (107-end) and Cyclin Y (2-end). AAA Biotech's PCTK1 can be used in a range of immunoassay formats including, but not limited to, Kinase Assay, Western Blot (WB). Researchers should empirically determine the suitability of the PCTK1 cdk16 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PCTK1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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