Mouse anti-Human PAX5 Monoclonal Antibody | anti-PAX5 antibody

Anti-PAX5 Mouse mAb

Cat. Num. AAA476332

• Gene Names: PAX5; ALL3; BSAP
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Synonyms: PAX5; Monoclonal Antibody; Anti-PAX5 Mouse mAb; BSAP; anti-PAX5 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 7D3
• Form/Format: Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer
• Sequence Length: 328

• Applicable Applications for anti-PAX5 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Purified recombinant fragment of human PAX5 (AA: 235-382) expressed in E Coli.

Western Blot (WB)

(Western blot analysis using PAX5 mAb against human PAX5 recombinant protein. (Expected MW is 41.2 kDa))

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded brain tumors tissues using PAX5 mouse mAb with DAB staining.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded endometrial cancer tissues using PAX5 mouse mAb with DAB staining.)

Related Product Information for anti-PAX5 antibody

Entrez Summary: This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t (9; 14) (p13; q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.

NCBI and Uniprot Product Information

• NCBI GI #: 525507362
• NCBI GeneID: 5079
• NCBI Accession #: NP_001267481.1
• NCBI GenBank Nucleotide #: NM_001280552.1
• UniProt Accession #: Q02548; O75933; Q5SFM2; Q6S728; A3QVP6; A3QVP7; A3QVP8; C0KTF6; C0KTF7; C0KTF8; C0KTF9; C0KTG0
• Molecular Weight: 45
• NCBI Official Full Name: paired box protein Pax-5 isoform 7
• NCBI Official Synonym Full Names: paired box 5
• NCBI Official Symbol: PAX5
• NCBI Official Synonym Symbols: ALL3; BSAP
• NCBI Protein Information: paired box protein Pax-5
• UniProt Protein Name: Paired box protein Pax-5
• Protein Family: Paired box protein
• UniProt Gene Name: PAX5
• UniProt Synonym Gene Names: BSAP

NCBI Description

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Uniprot Description

May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.