Western Blot (WB)
(Western blot detection of SUZ12 in Jurkat, A549 and MCF7 cell lysates using SUZ12 mouse mAb (1:1000 diluted).Predicted band size:83KDa.Observed band size:83KDa.)
Mouse anti-Human SUZ12 Monoclonal Antibody | anti-SUZ12 antibody
Anti-SUZ12 Mouse mAb
Western Blot (WB)
(Western blot detection of SUZ12 in Jurkat, A549 and MCF7 cell lysates using SUZ12 mouse mAb (1:1000 diluted).Predicted band size:83KDa.Observed band size:83KDa.)
Western Blot (WB)
(Western blot detection of SUZ12 in Jurkat, A549 and MCF7 cell lysates using SUZ12 mouse mAb (1:1000 diluted).Predicted band size:83KDa.Observed band size:83KDa.)
Immunofluorescence (IF)
(Immunofluorescence analysis of U251 cells using SUZ12 mouse mAb (green). Red)
Immunofluorescence (IF)
(Immunofluorescence analysis of U251 cells using SUZ12 mouse mAb (green). Red)
Immunofluorescence (IF)
(Immunofluorescence analysis of MCF-7 cells using SUZ12 mouse mAb (green). Red)
Immunofluorescence (IF)
(Immunofluorescence analysis of MCF-7 cells using SUZ12 mouse mAb (green). Red)
UniPort Summary Function: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates Lys-9 (H3K9me) and Lys-27 (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
NCBI and Uniprot Product Information
NCBI Description
This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]
Uniprot Description
SUZ12: a zinc finger protein. A breakpoint translocation of the cognate gene with JAZF1 has been reported in endometrial stromal sarcoma.
Protein type: C2H2-type zinc finger protein; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: ESC/E(Z) complex; nucleolus; nucleoplasm; nucleus
Molecular Function: chromatin DNA binding; histone methyltransferase activity; methylated histone residue binding; protein binding
Biological Process: negative regulation of cell differentiation; negative regulation of gene expression, epigenetic; regulation of transcription, DNA-dependent
Research Articles on SUZ12
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Product Notes
The SUZ12 suz12 (Catalog #AAA476107) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-SUZ12 Mouse mAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SUZ12 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the SUZ12 suz12 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SUZ12, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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