Western Blot (WB)
(Mouse Erbb2 Antibody (Center) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the Erbb2 antibody detected the Erbb2 protein (arrow).)
Rabbit anti-Mouse Erbb2 Polyclonal Antibody | anti-Erbb2 antibody
Mouse Erbb2 Antibody (Center)
Western Blot (WB)
(Mouse Erbb2 Antibody (Center) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the Erbb2 antibody detected the Erbb2 protein (arrow).)
Western Blot (WB)
(Mouse Erbb2 Antibody (Center) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the Erbb2 antibody detected the Erbb2 protein (arrow).)
Johnson, E., et al. J. Biol. Chem. 285(38):29491-29501(2010)
Huck, L., et al. Proc. Natl. Acad. Sci. U.S.A. 107(35):15559-15564(2010)
Chuang, T.D., et al. J. Biol. Chem. 285(31):23598-23606(2010)
Simeone, L., et al. J. Neurosci. 30(19):6620-6634(2010)
NCBI and Uniprot Product Information
Uniprot Description
HER2: a proto-oncogenic receptor tyrosine kinase of the EGFR family. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. Not activated by EGF, TGF- alpha and amphiregulin. Amplified in breast cancer. Overexpression induces constitutive activity, and the gene is amplified or overexpressed in up to 30% of breast cancers, correlating with poor survival. The antibody Herceptin is approved for treatment of metastatic breast cancer with HER2 amplification/overexpression. Somatic mutations seen in 4% of lung cancers and also in breast, gastric, ovarian cancer and glioblastoma. One SNP shows predisposition to breast and gastric cancer. Inhibitors: Herceptin, lapatinib, PKI-166, EKB-569, CI-1033.
Protein type: EC 2.7.10.1; Protein kinase, tyrosine (receptor); Protein kinase, TK; Membrane protein, integral; Kinase, protein; Oncoprotein; TK group; EGFR family
Cellular Component: microvillus; lateral loop; basolateral plasma membrane; integral to membrane; lipid raft; postsynaptic membrane; membrane; perinuclear region of cytoplasm; cytoplasm; apical plasma membrane; basal plasma membrane; plasma membrane; endosome membrane; cytoplasmic vesicle; nucleus; receptor complex
Molecular Function: protein C-terminus binding; identical protein binding; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; Hsp90 protein binding; protein phosphatase binding; protein kinase activity; transferase activity; protein binding; transmembrane receptor activity; protein heterodimerization activity; growth factor binding; protein-tyrosine kinase activity; ubiquitin protein ligase binding; transferase activity, transferring phosphorus-containing groups; kinase activity; glycoprotein binding; ATP binding
Biological Process: myelination; phosphoinositide 3-kinase cascade; peptidyl-tyrosine phosphorylation; positive regulation of cell adhesion; positive regulation of translation; wound healing; heart development; protein amino acid autophosphorylation; motor axon guidance; signal transduction; protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase I promoter; positive regulation of MAP kinase activity; sympathetic nervous system development; cell surface receptor linked signal transduction; glial cell differentiation; regulation of transcription, DNA-dependent; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; oligodendrocyte differentiation; response to axon injury; neuromuscular junction development; negative regulation of immature T cell proliferation in the thymus; regulation of microtubule-based process; nervous system development; transcription, DNA-dependent; positive regulation of cell growth; peripheral nervous system development; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of transcription from RNA polymerase III promoter; positive regulation of protein amino acid phosphorylation; positive regulation of Ras protein signal transduction; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of epithelial cell proliferation; positive regulation of GTPase activity; negative regulation of apoptosis
Research Articles on Erbb2
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Product Notes
The Erbb2 erbb2 (Catalog #AAA9207751) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 531-559. The Mouse Erbb2 Antibody (Center) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Erbb2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the Erbb2 erbb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Erbb2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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