Human Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1) ELISA Kit | ROR1 elisa kit

Human Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1) ELISA Kit

Cat. Num. AAA456118

• Gene Names: ROR1; NTRKR1; dJ537F10.1
• Reactivity: Human
• Synonyms: Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1); Human Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1) ELISA Kit; ROR1 elisa kit

• Reactivity: Human
• Sequence Length: 393

• Samples: Tissue homogenates, cell lysates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 0.156-10ng/mL
• Sensitivity: 0.054ng/mL
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 134152686
• NCBI GeneID: 4919
• NCBI Accession #: NP_001077061.1
• NCBI GenBank Nucleotide #: NM_001083592.1
• UniProt Accession #: Q01973; Q5VVX6; Q66K77; Q92776
• Molecular Weight: 43,826 Da
• NCBI Official Full Name: inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 2
• NCBI Official Synonym Full Names: receptor tyrosine kinase like orphan receptor 1
• NCBI Official Symbol: ROR1
• NCBI Official Synonym Symbols: NTRKR1; dJ537F10.1
• NCBI Protein Information: inactive tyrosine-protein kinase transmembrane receptor ROR1
• UniProt Protein Name: Inactive tyrosine-protein kinase transmembrane receptor ROR1
• Protein Family: Inactive tyrosine-protein kinase transmembrane receptor
• UniProt Gene Name: ROR1
• UniProt Synonym Gene Names: NTRKR1

NCBI Description

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

Uniprot Description

Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.