Interferon alpha-2b Active Protein | INF alpha-2b active protein
Human Interferon alpha-2b (INF alpha-2b), yeast
Purity
> 97% (by SDS-PAGE and HPLC)
Synonyms
Interferon alpha-2b; Human Interferon alpha-2b (INF alpha-2b); yeast; Human Interferon Alfa-2b (INF alpha-2b); human interferon alpha-2b; INF alpha-2b active protein
Host
Yeast
Purity/Purification
> 97% (by SDS-PAGE and HPLC)
Form/Format
Lyophilized from a 0.2mum filtered solution in 20mM Phosphate Buffer
Reconstitute with double distilled water at a concentration of no less than 1 mug/ml with 0.1% human serum albumin (A highly purified plant-derived human serum albumin is strongly sug
Reconstitute with double distilled water at a concentration of no less than 1 mug/ml with 0.1% human serum albumin (A highly purified plant-derived human serum albumin is strongly sug
Endotoxin Level
<=1 EU/mg, determined by the LAL method
Biological Activity
Bioactivity is detected using cytopathic effect inhibition assay method, WISH cell (a heteroploid human amnion cell line) as dependent cell strain. The specific activity shall be not less than 2.0×108 IU/mg.
Preparation and Storage
Stable for 6-months from the date of shipment when kept at -20 degree C or -70 degree C. Upon reconstitution, it can be stored at 4 degree C for at least one month or -20 degree C for at least three months. Avoid repeated freeze-thaw cycles.
Related Product Information for INF alpha-2b active protein
Description: Recombinant human IFN alpha-2b produced in Yeast is a single, non-glycosylated, polypeptide chain containing 165 amino acids, two pairs of disulfide bonds and having a molecular mass of approximately 19.3kD.
Introduction: Human Interferon alpha-2b is a single polypeptide chain of 165 amino acids residues, containing 4 Cys to form two disulfide bonds at positions of Cys 1- Cys 98 and Cys 29-Cys 138, and it has a molecular mass of approximately 19.3 kD. IFN can exert certain cell activities through binding to specific cell surface receptors, as firstly induce to develop special proteins, such as protein kinase and 2', 5'-oligo polyadenylic acid synthase etc. The unique character of two enzymes is that they can be activated respectively by double chains RNA to produce the effect of self-phosphorylation. INF can also enhance phagocytosis activity of macrophage and special toxicity of lymphocyte to target cells to cause immunoloregulation. Its biological effects contains: (1) Anti-virus: INF alpha has broad-spectrum anti-virus effect; (2) Cytostatic effect to certain cells; (3) Immunoloregulation effect: accelerate the expression of MHC antigen by most cell and active NK cell and CTL. (4) Repress and kill tumor cells: INF-alpha kill the tumor cells through accelerating the immunological function and enhancing the killing ability of macrophage, NK and CTL.
Introduction: Human Interferon alpha-2b is a single polypeptide chain of 165 amino acids residues, containing 4 Cys to form two disulfide bonds at positions of Cys 1- Cys 98 and Cys 29-Cys 138, and it has a molecular mass of approximately 19.3 kD. IFN can exert certain cell activities through binding to specific cell surface receptors, as firstly induce to develop special proteins, such as protein kinase and 2', 5'-oligo polyadenylic acid synthase etc. The unique character of two enzymes is that they can be activated respectively by double chains RNA to produce the effect of self-phosphorylation. INF can also enhance phagocytosis activity of macrophage and special toxicity of lymphocyte to target cells to cause immunoloregulation. Its biological effects contains: (1) Anti-virus: INF alpha has broad-spectrum anti-virus effect; (2) Cytostatic effect to certain cells; (3) Immunoloregulation effect: accelerate the expression of MHC antigen by most cell and active NK cell and CTL. (4) Repress and kill tumor cells: INF-alpha kill the tumor cells through accelerating the immunological function and enhancing the killing ability of macrophage, NK and CTL.
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Product Notes
The INF alpha-2b (Catalog #AAA434173) is an Active Protein produced from Yeast and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Interferon alpha-2b, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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