Calcitonin gene-related peptide 1 Recombinant Protein | CALCA recombinant protein

Recombinant Human Calcitonin gene-related peptide 1

Cat. Num. AAA1265589

• Gene Names: CALCA; CT; KC; PCT; CGRP; CALC1; CGRP1; CGRP-I
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Calcitonin gene-related peptide 1; Recombinant Human Calcitonin gene-related peptide 1; Alpha-type CGRP; Calcitonin gene-related peptide I; CGRP-I; CALCA recombinant protein

• Host: E Coli
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Liquid containing glycerol
• Sequence Positions: 83-118aa; Partial
• Sequence: ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKA
• Sequence Length: 128

• Production Note: Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to [email protected] for more details.
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for CALCA recombinant protein

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.

Product Categories/Family for CALCA recombinant protein

Signal Transduction

References

Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression.Jonas V., Lin C.R., Kawashima E., Semon D., Swanson L.W., Mermod J.-J., Evans R.M., Rosenfeld M.G.Proc. Natl. Acad. Sci. U.S.A. 82:1994-1998(1985) Structure and methylation of the human calcitonin/alpha-CGRP gene.Broad P.M., Symes A.J., Thakker R.V., Craig R.K.Nucleic Acids Res. 17:6999-7011(1989) Human chromosome 11 DNA sequence and analysis including novel gene identification.Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.Nature 440:497-500(2006) Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide.Nelkin B.D., Rosenfeld K.I., de Bustros A., Leong S.S., Roos B.A., Baylin S.B.Biochem. Biophys. Res. Commun. 123:648-655(1984) Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma.Edbrooke M.R., Parker D., McVey J.H., Riley J.H., Sorenson G.D., Pettengill O.S., Craig R.K.EMBO J. 4:715-724(1985) Calcitonin gene related peptide coding sequence is conserved in the human genome and is expressed in medullary thyroid carcinoma.Steenbergh P.H., Hoppener J.W., Zandberg J., de Ven W.J., Jansz H.S., Lips C.J.J. Clin. Endocrinol. Metab. 59:358-360(1984) Expression and function of the human calcitonin/alpha-CGRP gene in health and disease.Craig R.K., Riley J.H., Edbrooke M.R., Broad P.M., Foord S.M., Al-Kazwini S.J., Holman J.J., Marshall I.Biochem. Soc. Symp. 52:91-105(1986) Isolation and characterization of human calcitonin gene-related peptide.Morris H.R., Panico M., Etienne T., Tippins J., Girgis S.I., McIntyre I.Nature 308:746-748(1984) Identification in the human central nervous system, pituitary, and thyroid of a novel calcitonin gene-related peptide, and partial amino acid sequence in the spinal cord.Petermann J.B., Born W., Chang J.Y., Fischer J.A.J. Biol. Chem. 262:542-545(1987) Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma.Kitamura K., Kangawa K., Kawamoto M., Ichiki Y., Matsuo H., Eto T.Biochem. Biophys. Res. Commun. 185:134-141(1992) Solution structure of human calcitonin gene-related peptide by 1H NMR and distance geometry with restrained molecular dynamics.Breeze A.L., Harvey T.S., Bazzo R., Campbell I.D.Biochemistry 30:575-582(1991) Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin.Hubbard J.A.M., Martin S.R., Chaplin L.C., Bose C., Kelly S.M., Price N.C.Biochem. J. 275:785-788(1991)

NCBI and Uniprot Product Information

• NCBI GI #: 76880478
• NCBI GeneID: 796
• NCBI Accession #: NP_001029125.1
• NCBI GenBank Nucleotide #: NM_001033953.2
• UniProt Accession #: P06881; Q93048; Q9UCP0; P01258
• Molecular Weight: 30.6 kDa
• NCBI Official Full Name: calcitonin gene-related peptide 1 isoform alpha-CGRP preproprotein
• NCBI Official Synonym Full Names: calcitonin-related polypeptide alpha
• NCBI Official Symbol: CALCA
• NCBI Official Synonym Symbols: CT; KC; PCT; CGRP; CALC1; CGRP1; CGRP-I
• NCBI Protein Information: calcitonin; calcitonin gene-related peptide 1
• UniProt Protein Name: Calcitonin gene-related peptide 1
• Protein Family: Calcitonin
• UniProt Gene Name: CALCA
• UniProt Synonym Gene Names: CALC1; CGRP-I
• UniProt Entry Name: CALCA_HUMAN

NCBI Description

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]

Uniprot Description

CALCA iso3: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p15.2

Cellular Component: cell soma; cytoplasm; cytosol; extracellular region; extracellular space; nucleus; terminal button

Molecular Function: calcitonin receptor binding; hormone activity; identical protein binding; protein binding; protein complex binding; receptor binding

Biological Process: activation of protein kinase activity; adenylate cyclase activation; aging; antibacterial humoral response; antifungal humoral response; cell-cell signaling; cellular protein metabolic process; cytosolic calcium ion homeostasis; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; detection of temperature stimulus involved in sensory perception of pain; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); embryo implantation; endothelial cell migration; endothelial cell proliferation; feeding behavior; G-protein coupled receptor internalization; G-protein signaling, adenylate cyclase activating pathway; inflammatory response; innate immune response; leukocyte adhesion; monocyte chemotaxis; negative regulation of blood pressure; negative regulation of bone resorption; negative regulation of neurological process; negative regulation of ossification; negative regulation of osteoclast differentiation; negative regulation of smooth muscle contraction; negative regulation of transcription, DNA-dependent; neuropeptide signaling pathway; positive regulation of adenylate cyclase activity; positive regulation of cAMP biosynthetic process; positive regulation of interleukin-1 alpha production; positive regulation of interleukin-8 production; positive regulation of macrophage differentiation; positive regulation of ossification; positive regulation of vasodilation; protein amino acid phosphorylation; receptor internalization; regulation of blood pressure; regulation of heart rate; regulation of systemic arterial blood pressure by neurological process; response to heat; response to pain; response to yeast; vasculature development; vasodilation of artery during baroreceptor response to increased systemic arterial blood pressure