Phosphodiesterase 1B Assay System | PDE1B assay system
Phosphodiesterase 1B (PDE1B) ACTOne Stable Cell Line, HEK293 cells
NCBI and Uniprot Product Information
NCBI Description
phosphodiesterase isozyme that catalyzes the calmodulin dependent hydrolysis of cGMP; expressed in brain [RGD, Feb 2006]
Uniprot Description
PDE1B: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate. Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Phosphodiesterase; Apoptosis; Nucleotide Metabolism - purine; EC 3.1.4.17
Cellular Component: cell soma; cytoplasm
Molecular Function: calmodulin binding; 3',5'-cyclic-AMP phosphodiesterase activity; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; metal ion binding; cyclic-nucleotide phosphodiesterase activity
Biological Process: monocyte differentiation; regulation of neurotransmitter levels; cAMP catabolic process; regulation of dopamine metabolic process; response to amphetamine; visual learning; locomotory behavior; cGMP catabolic process; signal transduction; serotonin metabolic process
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Product Notes
The PDE1B pde1b (Catalog #AAA433638) is an Assay System and is intended for research purposes only. The product is available for immediate purchase. cAMP dependent human PDE1B cell-based assay; cell-based high-throughput screening of human PDE1B inhibitors. Researchers should empirically determine the suitability of the PDE1B pde1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Phosphodiesterase 1B, Assay System" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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