DLL4 blocking peptide

DLL4 Immunizing Peptide

Cat. Num. AAA428463

• Gene Names: DLL4; AOS6; hdelta2
• Reactivity: Human, Mouse, Rat
• Synonyms: DLL4; DLL4 Immunizing Peptide; delta-like 4 (Drosophila); MGC126344; hdelta2; delta 4; delta ligand 4; delta-like 4 homolog; delta-like 4 protein; notch ligand DLL4; notch ligand delta-2; DLL4 blocking peptide

• Reactivity: Human, Mouse, Rat
• Form/Format: 100ug of dried peptide
• Sequence: KNTNQKKELEVDC
• Sequence Length: 685

• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 9506545
• NCBI GeneID: 54567
• NCBI Accession #: NP_061947.1
• NCBI GenBank Nucleotide #: NM_019074.3
• Molecular Weight: 74,605 Da
• NCBI Official Full Name: delta-like protein 4
• NCBI Official Synonym Full Names: delta like canonical Notch ligand 4
• NCBI Official Symbol: DLL4
• NCBI Official Synonym Symbols: AOS6; hdelta2
• NCBI Protein Information: delta-like protein 4
• UniProt Protein Name: Delta-like protein 4
• Protein Family: Delta-like protein
• UniProt Gene Name: DLL4
• UniProt Synonym Gene Names: Delta4
• UniProt Entry Name: DLL4_HUMAN

NCBI Description

This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]

Uniprot Description

DLL4: Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4. Binds to Notch-1 and Notch-4. Expressed in vascular endothelium.

Protein type: Cell development/differentiation; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: integral to membrane; plasma membrane

Molecular Function: calcium ion binding; Notch binding; protein binding

Biological Process: angiogenesis; blood circulation; blood vessel remodeling; negative regulation of cell proliferation; negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter; Notch receptor processing; Notch signaling pathway; patterning of blood vessels; positive regulation of Notch signaling pathway; regulation of neurogenesis; signal transduction; T cell differentiation; visual perception

Disease: Adams-oliver Syndrome 6