FTO blocking peptide
FTO Immunizing Peptide
NCBI and Uniprot Product Information
Uniprot Description
FTO: Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation. Defects in FTO are the cause of growth retardation developmental delay coarse facies and early death (GDFD). A severe polymalformation syndrome characterized by postnatal growth retardation, microcephaly, severe psychomotor delay, functional brain deficits and characteristic facial dysmorphism. In some patients, structural brain malformations, cardiac defects, genital anomalies, and cleft palate are observed. Early death occurs by the age of 3 years. Belongs to the fto family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.14.11.-
Cellular Component: nuclear speck; nucleus
Molecular Function: 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity; dioxygenase activity; DNA-N1-methyladenine dioxygenase activity; ferrous iron binding; metal ion binding; oxidoreductase activity; procollagen-proline dioxygenase activity; sulfonate dioxygenase activity
Biological Process: DNA dealkylation; DNA repair; regulation of multicellular organism growth; response to DNA damage stimulus; RNA repair; thermoregulation
Research Articles on FTO
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Product Notes
The FTO fto (Catalog #AAA426454) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The FTO Immunizing Peptide reacts with Human, Mouse, Rat, Dog, Pig and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: QQKPDCRPYW EKDD. It is sometimes possible for the material contained within the vial of "FTO, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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