Netrin 1 Blocking Peptide | NTN1 blocking peptide
Netrin 1 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008]
Uniprot Description
NTN1: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: basement membrane; cytoplasm; extracellular region
Molecular Function: protein binding
Biological Process: anterior/posterior axon guidance; apoptosis; axon guidance; Cdc42 protein signal transduction; cell-cell adhesion; establishment of nucleus localization; inner ear morphogenesis; negative regulation of axon extension; neuron migration; positive regulation of axon extension; positive regulation of cell proliferation; Ras protein signal transduction; regulation of cell migration; substrate-bound cell migration, cell extension
Research Articles on NTN1
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Product Notes
The NTN1 ntn1 (Catalog #AAA426211) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The Netrin 1 Immunizing Peptide reacts with Human, Mouse, Rat, Dog, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: KFQQREKKGK CKKA. It is sometimes possible for the material contained within the vial of "Netrin 1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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