BAG3 / BIS/ CAIR1 Blocking Peptide | BAG3 blocking peptide

BAG3 / BIS/ CAIR1 Immunizing Peptide

Cat. Num. AAA425472

• Gene Names: BAG3; BIS; MFM6; BAG-3; CAIR-1
• Reactivity: Human
• Synonyms: BAG3 / BIS/ CAIR1; BAG3 / BIS/ CAIR1 Immunizing Peptide; BAG3; BCL2-associated athanogene 3; BIS; BAG-3; CAIR-1; MGC104307; DKFZp434E0610; Bcl-2-binding protein; docking protein CAIR-1; BCL2-binding athanogene 3; BAG-family molecular chaperone regulator-3; BAG3 blocking peptide

• Reactivity: Human
• Form/Format: 100ug of dried peptide
• Sequence: C-SSMTDTPGNPAAP
• Sequence Length: 575

• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 14043024
• NCBI GeneID: 9531
• NCBI Accession #: NP_004272.2
• NCBI GenBank Nucleotide #: NM_004281.3
• Molecular Weight: 61,595 Da
• NCBI Official Full Name: BAG family molecular chaperone regulator 3
• NCBI Official Synonym Full Names: BCL2 associated athanogene 3
• NCBI Official Symbol: BAG3
• NCBI Official Synonym Symbols: BIS; MFM6; BAG-3; CAIR-1
• NCBI Protein Information: BAG family molecular chaperone regulator 3
• UniProt Protein Name: BAG family molecular chaperone regulator 3
• Protein Family: BAG family molecular chaperone regulator
• UniProt Gene Name: BAG3
• UniProt Synonym Gene Names: BIS; BAG-3
• UniProt Entry Name: BAG3_HUMAN

NCBI Description

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]

Uniprot Description

BAG3: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity. Defects in BAG3 are the cause of myopathy myofibrillar type 6 (MFM6). A neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. At ultrastructural level, muscle fibers display structural alterations consisting of replacement of the normal myofibrillar markings by small, dense granules, or larger hyaline masses, or amorphous material. Defects in BAG3 are the cause of cardiomyopathy dilated type 1HH (CMD1HH). CMD1HH is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 10q25.2-q26.2

Cellular Component: cytoplasm; cytosol; neuron projection; plasma membrane; Z disc

Molecular Function: adenyl-nucleotide exchange factor activity; chaperone binding; protein binding; protein complex binding

Biological Process: brain development; induction of apoptosis via death domain receptors; negative regulation of apoptosis; protein folding; protein stabilization; regulation of catalytic activity; spinal cord development

Disease: Cardiomyopathy, Dilated, 1hh; Myopathy, Myofibrillar, 6