PGC1A Blocking Peptide | PPARGC1A blocking peptide
PGC1A Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]
Uniprot Description
PGC-1 alpha: a transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor genes. Interacts with, and regulates the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). Regulates many genes involved in energy metabolism. Provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. May be involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. Its transcription is repressed by ZNF746 which binds to 'insulin response sequences' in its promoter. Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 4p15.1
Cellular Component: cell soma; DNA-directed RNA polymerase II, core complex; nucleoplasm; nucleus; PML body
Molecular Function: alpha-tubulin binding; androgen receptor binding; chromatin DNA binding; DNA binding; estrogen receptor binding; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nucleotide binding; peroxisome proliferator activated receptor binding; protein binding; RNA binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor binding; ubiquitin protein ligase binding
Biological Process: aging; androgen metabolic process; androgen receptor signaling pathway; brown fat cell differentiation; cell glucose homeostasis; cellular respiration; cerebellum development; circadian regulation of gene expression; circadian rhythm; digestion; fatty acid oxidation; flavone metabolic process; forebrain development; galactose metabolic process; gluconeogenesis; mitochondrion degradation; mitochondrion organization and biogenesis; mRNA processing; negative regulation of glycolysis; negative regulation of neuron apoptosis; negative regulation of protein amino acid phosphorylation; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; positive regulation of fatty acid oxidation; positive regulation of gluconeogenesis; positive regulation of histone acetylation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter by pheromones; positive regulation of transcription, DNA-dependent; protein complex assembly; protein stabilization; regulation of circadian rhythm; regulation of transcription, DNA-dependent; response to cold; response to dietary excess; response to electrical stimulus involved in regulation of muscle adaptation; response to leucine; response to muscle activity; response to reactive oxygen species; response to starvation; RNA splicing; skeletal muscle atrophy; thermoregulation; transcription initiation from RNA polymerase II promoter
Research Articles on PPARGC1A
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Product Notes
The PPARGC1A ppargc1a (Catalog #AAA425040) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The PGC1A Immunizing Peptide reacts with Human, Mouse, Rat, Dog and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-DGLFDDSE DESDK. It is sometimes possible for the material contained within the vial of "PGC1A, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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