Western Blot (WB)
((1ug/ml) staining of Mouse Lung lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Goat FOXF1 Polyclonal Antibody | anti-FOXF1 antibody
Goat anti-FOXF1 Antibody
Western Blot: Approx 37kDa band observed in Mouse Lung lysates (calculated MW of 40. 0kDa according to Mouse NP_034556.2). Recommended concentration: 1-3ug/ml.
Western Blot (WB)
((1ug/ml) staining of Mouse Lung lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Western Blot (WB)
((1ug/ml) staining of Mouse Lung lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008]
Uniprot Description
FOXF1: Probable transcription activator for a number of lung- specific genes. Defects in FOXF1 are the cause of alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV). ACDMPV is a rare malformation due to abnormal development of the capillary vascular system in the lungs. Histologically, it is characterized by failure of formation and ingrowth of alveolar capillaries, medial muscular thickening of small pulmonary arterioles with muscularization of the intraacinar arterioles, thickened alveolar walls, and anomalously situated pulmonary veins running alongside pulmonary arterioles and sharing the same adventitial sheath. Less common features include a reduced number of alveoli and a patchy distribution of the histopathologic changes. Affected infants present with respiratory distress and the disease is fatal within the newborn period. Additional features include multiple congenital anomalies affecting the cardiovascular, gastrointestinal, genitourinary, and musculoskeletal systems, as well as disruption of the normal right-left asymmetry of intrathoracic or intraabdominal organs. ACDMPV is a rare cause of persistent pulmonary hypertension of the newborn, an abnormal physiologic state caused by failure of transition of the pulmonary circulation from the high pulmonary vascular resistance of the fetus to the low pulmonary vascular resistance of the newborn.
Protein type: Transcription factor; DNA-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16q24
Cellular Component: nucleus; transcription factor complex
Molecular Function: DNA binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding
Biological Process: alveolus development; blood vessel development; cell-cell adhesion; detection of wounding; determination of left/right symmetry; embryonic digestive tract morphogenesis; embryonic ectodermal gut morphogenesis; embryonic foregut morphogenesis; establishment of epithelial cell polarity; extracellular matrix organization and biogenesis; gut development; heart development; in utero embryonic development; lateral mesodermal cell differentiation; lung development; midgut development; morphogenesis of a branching structure; negative regulation of inflammatory response; negative regulation of mast cell degranulation; negative regulation of transcription from RNA polymerase II promoter; pancreas development; positive regulation of cell migration; positive regulation of mesenchymal cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of smooth muscle cell differentiation; respiratory tube development; smooth muscle cell differentiation; smoothened signaling pathway; somitogenesis; transcription from RNA polymerase II promoter; vasculogenesis
Disease: Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Research Articles on FOXF1
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Product Notes
The FOXF1 foxf1 (Catalog #AAA423481) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-FOXF1 Antibody reacts with Tested: Mouse; Expected from sequence similarity: Human, Mouse, Dog, Cow and may cross-react with other species as described in the data sheet. AAA Biotech's FOXF1 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB). Peptide ELISA: Antibody detection limit dilution 1: 128000. Western Blot: Approx 37kDa band observed in Mouse Lung lysates (calculated MW of 40. 0kDa according to Mouse NP_034556.2). Recommended concentration: 1-3ug/ml. Researchers should empirically determine the suitability of the FOXF1 foxf1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: HQQVTYQDIK PC. It is sometimes possible for the material contained within the vial of "FOXF1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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