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Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded mouse heart using MBS7604035 (SGCE Antibody) at dilution of 1:100)

Rabbit SGCE Polyclonal Antibody | anti-SGCE antibody

SGCE Rabbit Polyclonal

Reactivity
Human, Mouse, Rat
Applications
ELISA, Immunofluorescence, Western Blot, Immunoprecipitation
Purity
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Synonyms
SGCE; Polyclonal Antibody; SGCE Rabbit Polyclonal; anti-SGCE antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Form/Format
Liquid
Sequence Length
437
Applicable Applications for anti-SGCE antibody
ELISA (EIA), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP)
Immunogen
Sarcoglycan, epsilon
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse heart using MBS7604035 (SGCE Antibody) at dilution of 1:100)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded mouse heart using MBS7604035 (SGCE Antibody) at dilution of 1:100)

Western Blot (WB)

(SW620 cells were subjected to SDS PAGE followed by western blot with MBS7604035 (SGCE antibody) at dilution of 1:1000)

Western Blot (WB) (SW620 cells were subjected to SDS PAGE followed by western blot with MBS7604035 (SGCE antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

NCBI GI #
Molecular Weight
52,525 Da
NCBI Official Full Name
SGCE
UniProt Protein Name
Epsilon-sarcoglycan
Protein Family
UniProt Gene Name
SGCE
UniProt Synonym Gene Names
ESG; Epsilon-SG
UniProt Entry Name
SGCE_HUMAN

Uniprot Description

SGCE: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCE are a cause of dystonia type 11 (DYT11); also known as myoclonic dystonia or alcohol- responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable. Belongs to the sarcoglycan alpha/epsilon family.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q21.3

Cellular Component: cytoskeleton; dendrite; dystrophin-associated glycoprotein complex; Golgi apparatus; integral to plasma membrane; plasma membrane; sarcoglycan complex; sarcolemma

Biological Process: cell-matrix adhesion; muscle development; muscle system process

Disease: Myoclonic Dystonia

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Product Notes

The SGCE sgce (Catalog #AAA7604035) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SGCE Rabbit Polyclonal reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SGCE can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the SGCE sgce for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SGCE, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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