Goat MRG/MORF4L Polyclonal Antibody | anti-MRGBP antibody

Goat anti-MRG/MORF4L binding protein Antibody

Cat. Num. AAA422905

• Gene Names: MRGBP; Eaf7; URCC4; MRG15BP; C20orf20
• Reactivity: Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Cow
• Applications: ELISA, Western Blot
• Purity: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Synonyms: MRG/MORF4L; Polyclonal Antibody; Goat anti-MRG/MORF4L binding protein Antibody; C20orf20; chromosome 20 open reading frame 20; Eaf7; FLJ10914; MRG15BP; MRGBP; URCC4; MRG(MORF4-related gene)-binding protein; MRG-binding protein; OTTHUMP00000031512; C20orf20 antibody; chromosome 20 open reading frame 20 antibody; Eaf7 antibody; FLJ10914 antibody; MRG(MORF4-related gene)-binding protein antibody; MRG15BP antibody; MRG-binding protein antibody; MRGBP antibody; OTTHUMP00000031512 antibody; URCC4 antibody; MRG/MORF4L binding protein antibody; MRG/MORF4L binding protein; anti-MRGBP antibody

• Host: Goat
• Reactivity: Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Cow
• Clonality: Polyclonal
• Purity/Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Form/Format: Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
• Concentration: 100ug specific antibody in 200ul (varies by lot)
• Sequence: CIRDKFSQNIGRQVP
• Sequence Length: 204

• Applicable Applications for anti-MRGBP antibody: Peptide ELISA (EIA), Western Blot (WB)
• Application Notes: Peptide ELISA: Antibody detection limit dilution 1: 32000.; Western Blot: Approx 21kDa band observed in Human Testis lysates (calculated MW of 22.4kDa according to NP_060740.1). Recommended concentration: 0.3-1ug/ml.
• Immunogen: Peptide with sequence CIRDKFSQNIGRQVP, from the internal region of the protein sequence according to NP_060740.1.
• Epitope: Internal region
• Preparation and Storage: Aliquot and store at -20 degree C. Minimize freezing and thawing.

Western Blot (WB)

((0.3ug/ml) staining of Human Testis lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)

NCBI and Uniprot Product Information

• NCBI GI #: 8922764
• NCBI GeneID: 55257
• NCBI Accession #: NP_060740.1
• NCBI GenBank Nucleotide #: NM_018270.5
• Molecular Weight: 22,417 Da
• NCBI Official Full Name: MRG/MORF4L-binding protein
• NCBI Official Synonym Full Names: MRG/MORF4L binding protein
• NCBI Official Symbol: MRGBP
• NCBI Official Synonym Symbols: Eaf7; URCC4; MRG15BP; C20orf20
• NCBI Protein Information: MRG/MORF4L-binding protein
• UniProt Protein Name: MRG/MORF4L-binding protein
• Protein Family: MRG/MORF4L-binding protein
• UniProt Gene Name: MRGBP
• UniProt Synonym Gene Names: C20orf20; Urcc4
• UniProt Entry Name: MRGBP_HUMAN

Uniprot Description

MRGBP: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Belongs to the EAF7 family.

Protein type: Acetyltransferase

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: NuA4 histone acetyltransferase complex; nucleoplasm; nucleus

Molecular Function: protein binding

Biological Process: histone acetylation; regulation of growth; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent