Goat ITPR3 Polyclonal Antibody | anti-ITPR3 antibody
Goat anti-ITPR3 Antibody
Western Blot: Preliminary experiments gave an approx 60kDa band in Human Adipose, Colon, Duodenum, Heart and Liver lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 304kDa according to NP_002215.1. The 60kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]
Uniprot Description
IP3R3: a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Expressed in intestinal crypt and villus epithelial cells. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues. Belongs to the InsP3 receptor family.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Channel, calcium
Chromosomal Location of Human Ortholog: 6p21
Cellular Component: apical part of cell; brush border; cell soma; cytoplasm; cytosol; dendrite; endoplasmic reticulum; endoplasmic reticulum membrane; integral to plasma membrane; membrane; myelin sheath; nuclear outer membrane; nucleolus; nucleoplasm; perinuclear region of cytoplasm; plasma membrane; receptor complex
Molecular Function: calcium ion binding; calcium-release channel activity; inositol 1,3,4,5 tetrakisphosphate binding; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity; inositol hexakisphosphate binding; phosphoinositide binding; protein binding
Biological Process: elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; inositol phosphate-mediated signaling; memory; platelet activation; protein heterooligomerization; protein homooligomerization; regulation of insulin secretion; release of sequestered calcium ion into cytosol; response to calcium ion; sensory perception of bitter taste; sensory perception of sweet taste; sensory perception of umami taste
Disease: Diabetes Mellitus, Insulin-dependent
Research Articles on ITPR3
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Product Notes
The ITPR3 itpr3 (Catalog #AAA420457) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-ITPR3 Antibody reacts with Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow and may cross-react with other species as described in the data sheet. AAA Biotech's ITPR3 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 128000. Western Blot: Preliminary experiments gave an approx 60kDa band in Human Adipose, Colon, Duodenum, Heart and Liver lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 304kDa according to NP_002215.1. The 60kDa band was successfully blocked by incubation with the immunizing peptide. Researchers should empirically determine the suitability of the ITPR3 itpr3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: DKKERPTDEE GFLH. It is sometimes possible for the material contained within the vial of "ITPR3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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