Western Blot/Blotting
(Western blot analysis)
Rabbit anti-Human Lysophosphatidic Acid 2 (LPA2) Receptor (EDG4) CT Polyclonal Antibody | anti-EDG4 antibody
Lysophosphatidic Acid 2 (LPA2) Receptor (EDG4) CT
Western Blot/Blotting
(Western blot analysis)
Western Blot/Blotting
(Western blot analysis)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G12/G13, and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation. Ref.9 Ref.11
Subunit structure: Interacts with SLC9A3R2/NHERF2, MAGI3 and PLCB3. Interacts with RALA and ADRBK1. Ref.9 Ref.10 Ref.11
Subcellular location: Cell surface. Cell membrane; Multi-pass membrane protein. Note: Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co-localizes with RALA in the endocytic vesicles. Ref.11
Tissue specificity: Expressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon.
Miscellaneous: Ref.1 cDNA clone has a guanine nucleotide deletion that causes a frameshift near its C-terminal coding region. This likely reflects a somatic mutation in the ovary tumor cells from which the cDNA was isolated and may have altered the function of the encoded receptor, and contributed to transformation of the original ovary cells that formed a tumor.
Sequence similarities: Belongs to the G-protein coupled receptor 1 family.
Sequence caution: The sequence AAC27728.1 differs from that shown. Reason: Frameshift at position 348.
Research Articles on EDG4
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Product Notes
The EDG4 lpar2 (Catalog #AAA395948) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Lysophosphatidic Acid 2 (LPA2) Receptor (EDG4) CT reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Lysophosphatidic Acid 2 (LPA2) Receptor (EDG4) CT can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the EDG4 lpar2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Lysophosphatidic Acid 2 (LPA2) Receptor (EDG4) CT, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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