Goat MURF1/TRIM63 Polyclonal Antibody | anti-TRIM63 antibody
Goat anti-MURF1/TRIM63 (internal) Antibody
Western Blot: Preliminary experiments gave an approx 75kDa band in human heart and skeletal muscle lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 40.2kDa according to NP_115977.2. The 75kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012]
Uniprot Description
MURF1: E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric- associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
Protein type: Ubiquitin conjugating system; EC 6.3.2.19; Ligase; EC 6.3.2.-; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 1p34-p33
Cellular Component: cytoplasm; M band; microtubule; nucleus; Z disc
Molecular Function: ligase activity; protein binding; signal transducer activity; titin binding; ubiquitin-protein ligase activity; zinc ion binding
Biological Process: muscle contraction; protein ubiquitination; response to electrical stimulus involved in regulation of muscle adaptation; response to glucocorticoid stimulus; signal transduction; skeletal muscle atrophy
Research Articles on TRIM63
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Product Notes
The TRIM63 trim63 (Catalog #AAA420150) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-MURF1/TRIM63 (internal) Antibody reacts with Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow and may cross-react with other species as described in the data sheet. AAA Biotech's MURF1/TRIM63 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Preliminary experiments gave an approx 75kDa band in human heart and skeletal muscle lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 40.2kDa according to NP_115977.2. The 75kDa band was successfully blocked by incubation with the immunizing peptide. Researchers should empirically determine the suitability of the TRIM63 trim63 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: QQYQEQLDKS TKLVE. It is sometimes possible for the material contained within the vial of "MURF1/TRIM63, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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