Western Blot (WB)
((0.1ug/ml) staining of Rat Spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Goat Ogg1 Polyclonal Antibody | anti-OGG1 antibody
Goat anti-Ogg1 (mouse) Antibody
Western Blot: Approx 37kDa band observed in Rat Spleen lysates (calculated MW of 38.7kDa according to Rat NP_110497.1 and 38.8kDa according to Mouse NP_035087.2). Recommended concentration: 0.1-0.3ug/ml.
Western Blot (WB)
((0.1ug/ml) staining of Rat Spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Western Blot (WB)
((0.1ug/ml) staining of Rat Spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
NCBI and Uniprot Product Information
Uniprot Description
OGG1: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion. Defects in OGG1 may be a cause of renal cell carcinoma (RCC). It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Belongs to the type-1 OGG1 family. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Deoxyribonuclease; Lyase; DNA repair, damage; EC 4.2.99.18
Cellular Component: mitochondrion; nuclear matrix; nuclear speck; nucleoplasm; nucleus; protein complex
Molecular Function: 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity; catalytic activity; damaged DNA binding; DNA binding; DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) lyase activity; DNA-3-methyladenine glycosylase III activity; hydrolase activity; hydrolase activity, acting on glycosyl bonds; lyase activity; microtubule binding; oxidized base lesion DNA N-glycosylase activity; oxidized purine base lesion DNA N-glycosylase activity; oxidized purine DNA binding; purine-specific mismatch base pair DNA N-glycosylase activity; single-strand selective uracil DNA N-glycosylase activity; uracil DNA N-glycosylase activity
Biological Process: aging; base-excision repair; DNA repair; metabolic process; negative regulation of apoptosis; nucleotide-excision repair; nucleotide-excision repair, DNA incision; regulation of protein import into nucleus, translocation; regulation of transcription, DNA-dependent; response to DNA damage stimulus; response to estradiol stimulus; response to oxidative stress; response to radiation
Research Articles on OGG1
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Product Notes
The OGG1 ogg1 (Catalog #AAA420013) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-Ogg1 (mouse) Antibody reacts with Tested: Rat; Expected from sequence similarity: Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Ogg1 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB). Peptide ELISA: Antibody detection limit dilution 1: 128000. Western Blot: Approx 37kDa band observed in Rat Spleen lysates (calculated MW of 38.7kDa according to Rat NP_110497.1 and 38.8kDa according to Mouse NP_035087.2). Recommended concentration: 0.1-0.3ug/ml. Researchers should empirically determine the suitability of the OGG1 ogg1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: HPKTSQAKGP SPLANK. It is sometimes possible for the material contained within the vial of "Ogg1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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