Mouse PTPMT1 Monoclonal Antibody | anti-PTPMT1 antibody

Anti-PTPMT1 Antibody

Cat. Num. AAA415111

• Gene Names: PTPMT1; MOSP; PLIP; DUSP23; PNAS-129
• Applications: ELISA, Western Blot
• Purity: Affinity purified
• Synonyms: PTPMT1; Monoclonal Antibody; Anti-PTPMT1 Antibody; anti-PTPMT1 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Specificity: Anti-PTPMT1 recognizes recombinant protein PTPMT1.
• Purity/Purification: Affinity purified
• Form/Format: Liquid
• Concentration: 100ug/100ul (varies by lot)
• Sequence Length: 2651

• Applicable Applications for anti-PTPMT1 antibody: ELISA (EIA), Western Blot (WB-Re)
• Application Notes: WB: 1:1000 analysis of recombinant protein PTPMT1 with Anti-PTPMT1
• Raised In: Purified mouse monoclonal antibody generated using E.coli expressed recombinant protein PTPMT1 as immunogen.
• Storage Buffer: citrate-tris-HCl buffer pH7.0 with 0.02% Proclin 300.
• Immunogen: Recombinant protein corresponding to full length PTPMT1.
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

References

None

NCBI and Uniprot Product Information

• NCBI GI #: 221218986
• NCBI GeneID: 114971
• NCBI Accession #: NP_783859.1
• NCBI GenBank Nucleotide #: NM_175732.2
• Molecular Weight: 16,459 Da
• NCBI Official Full Name: Homo sapiens protein tyrosine phosphatase, mitochondrial 1 (PTPMT1), transcript variant 1, mRNA
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, mitochondrial 1
• NCBI Official Symbol: PTPMT1
• NCBI Official Synonym Symbols: MOSP; PLIP; DUSP23; PNAS-129
• NCBI Protein Information: phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1; NB4 apoptosis/differentiation related protein; PTEN-like phosphatase; phosphoinositide lipid phosphatase; protein-tyrosine phosphatase mitochondrial 1
• UniProt Protein Name: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
• Protein Family: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase
• UniProt Gene Name: PTPMT1
• UniProt Entry Name: PTPM1_HUMAN

Uniprot Description

PTPMT1: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.48; Phosphatase, lipid; EC 3.1.3.27; Mitochondrial; EC 3.1.3.16; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: mitochondrion; integral to mitochondrial inner membrane; nucleus

Molecular Function: protein tyrosine/serine/threonine phosphatase activity; phosphoinositide 5-phosphatase activity; phosphatidylglycerophosphatase activity; protein tyrosine phosphatase activity

Biological Process: cardiolipin biosynthetic process; phosphatidylglycerol biosynthetic process; inositol phosphate dephosphorylation; phospholipid metabolic process; glycerophospholipid biosynthetic process; protein amino acid dephosphorylation