SDS-Page
(Recombinant FBPase1 protein gel 12.5% SDS-PAGE gel with Coomassie blue staining MW: 37.9 kDa Purity: >90%)
FBPase1 recombinant protein
Recombinant FBPase1 protein
Shipping Temp: Dry Ice
SDS-Page
(Recombinant FBPase1 protein gel 12.5% SDS-PAGE gel with Coomassie blue staining MW: 37.9 kDa Purity: >90%)
SDS-Page
(Recombinant FBPase1 protein gel 12.5% SDS-PAGE gel with Coomassie blue staining MW: 37.9 kDa Purity: >90%)
Background: FBPase1 (D-Fructose-1,6-Bisphosphate 1-Phosphohydrolase 1), also called as FBP1, is a gluconeogenesis regulatory enzyme. It catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. FBPase1 plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. It appears to modulate glycerol gluconeogenesis in liver and to be an important regulator of appetite and adiposity. Increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. Diseases associated with FBPase1 include Fructose-1,6-Bisphosphatase Deficiency and Metabolic Acidosis. Among its related pathways are Glucose metabolism and Carbon metabolism.
NCBI and Uniprot Product Information
NCBI Description
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]
Uniprot Description
FBPase: a key enzyme of gluconeogenesis that catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate, a precursor to glucose 6-phosphate. A regulator of glucose synthesis from non-carbohydrates. Two paralogs of this enzyme exists in humans, FBP1 in the liver and FBP2 in muscle. While both forms are inhibited allosterically by AMP, NAD and Ca2+, the muscle form is about 100-fold more sensitive to AMP and NAD, and about 1000-fold more sensitive to inhibition by Ca2+. Forms homotetramers that are stabilized in the active state by divalent cations (Mg2+, Mn2+ , Co+2, or Zn2+). Deficiency of FBP1 leads to a disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Phosphatase (non-protein); EC 3.1.3.11; Mitochondrial; Carbohydrate Metabolism - pentose phosphate pathway; Carbohydrate Metabolism - fructose and mannose
Chromosomal Location of Human Ortholog: 9q22.3
Cellular Component: cytoplasm; cytosol
Molecular Function: monosaccharide binding; identical protein binding; protein binding; metal ion binding; fructose-bisphosphatase activity; AMP binding
Biological Process: dephosphorylation; carbohydrate metabolic process; glucose metabolic process; negative regulation of Ras protein signal transduction; regulation of gluconeogenesis; pathogenesis; negative regulation of cell growth; fructose 6-phosphate metabolic process; negative regulation of glycolysis; fructose metabolic process; protein homotetramerization; gluconeogenesis
Disease: Fructose-1,6-bisphosphatase Deficiency
Research Articles on FBPase1
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Product Notes
The FBPase1 fbp1 (Catalog #AAA389351) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "FBPase1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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