c-Myc/MAX recombinant protein

Recombinant c-Myc/MAX complex

Cat. Num. AAA389144

• Synonyms: c-Myc/MAX; Recombinant c-Myc/MAX complex; c-Myc/MAX recombinant protein

• Host: Baculovirus
• Form/Format: Recombinant c-Myc/MAX Complex is supplied in 25mM HEPES-NaOH pH7.5, 300mM NaCl, 10% glycerol, 0.04% Triton X-100 and 0.5mM TCEP.

• Protein Species: Human
• Tag: DYKDDDDK-Tag, His-Tag
• Notes: This product was manufactured as described in Protein Details. Where possible, We has developed functional or activity assays for recombinant proteins. Additional characterization such as enzyme kinetic activity assays, inhibitor screening or other biological activity assays may not have been performed for every product. All available data for a given product is shown on the lot-specific Technical Data Sheet.
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.; Shipping Temp: Dry Ice

SDS-Page

(Recombinant c-Myc / MAX Complex 10% SDS-PAGE Coomassie staining Molecular Weights: c-Myc: 51.8 kDa MAX: 20.6 kDa Purity: >85% )

Related Product Information for c-Myc/MAX recombinant protein

Short Description: Recombinant c-Myc/MAX complex that includes human c-Myc amino acids 2-454 (accession number NP_002458.2) with an N-terminal DYKDDDDK tag and full-length human MAX protein (accession number NP_660087.1) with an N-terminal 6xHis-tag was expressed in Sf9 cells. The molecular weights of c-Myc (2-454) and MAX are 51.8 kDa and 20.6 kDa, respectively.

Background: c-Myc (MYC Proto-Oncogene, BHLH Transcription Factor), also known as MYCC or MRTL, is a transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5-CAC[GA]TG-3. Diseases associated with MYC include Burkitt Lymphoma and Precursor T-Cell Acute Lymphoblastic Leukemia. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and IL-2 Pathway. c-Myc can activate the transcription of growth-related genes. MAX (MYC Associated Factor X), also known as BHLHd4, is a member of transcription regulators. MAX forms a sequence-specific DNA-binding protein complex with MYC or MAD, and the MYC/MAX complex is a transcriptional activator, whereas the MAD/MAX complex is a repressor. It may repress transcription via the recruitment of a chromatin remodeling complex containing H3 Lys-9 histone methyltransferase activity. c-Myc/MAX complex can specifically recognize the core sequence 5-CAC[GA]TG-3 and bind to the E box DNA consensus sequence and regulates the transcription of specific target genes.

Product Categories/Family for c-Myc/MAX recombinant protein

Recombinant Proteins; Transcription

NCBI and Uniprot Product Information

• Molecular Weight: Molecular weights of c-Myc (2-454) and MAX are 51.8 kDa and 20.6 kDa