Human Tissue Inhibitors Of Metalloproteinase 4 (TIMP-4) ELISA Kit | TIMP-4 elisa kit

Human Tissue Inhibitors Of Metalloproteinase 4 (TIMP-4) ELISA Kit

Cat. Num. AAA3802642

• Gene Names: TIMP4; TIMP-4
• Reactivity: Human
• Synonyms: Tissue Inhibitors Of Metalloproteinase 4 (TIMP-4); Human Tissue Inhibitors Of Metalloproteinase 4 (TIMP-4) ELISA Kit; TIMP-4 elisa kit

• Reactivity: Human
• Sequence Length: 224

• Samples: Serum, plasma, cell culture supernate and other biological fluids
• Assay Type: Sandwich
• Detection Range: 1.25ng/ml-20ng/ml
• Sensitivity: 0.1 ng/ml

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for TIMP-4 elisa kit

Intended Use: The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration ofTIMP-4 ANTIBODYin the sample, This TIMP-4 ANTIBODYELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versusTIMP-4 ANTIBODYconcentration. The concentration ofTIMP-4 ANTIBODYin the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 4507515
• NCBI GeneID: 7079
• NCBI Accession #: NP_003247.1
• NCBI GenBank Nucleotide #: NP_003247.1
• UniProt Accession #: Q99727
• NCBI Official Full Name: metalloproteinase inhibitor 4
• NCBI Official Synonym Full Names: TIMP metallopeptidase inhibitor 4
• NCBI Official Symbol: TIMP4
• NCBI Official Synonym Symbols: TIMP-4
• NCBI Protein Information: metalloproteinase inhibitor 4
• UniProt Protein Name: Metalloproteinase inhibitor 4
• UniProt Gene Name: TIMP4
• UniProt Synonym Gene Names: TIMP-4
• UniProt Entry Name: TIMP4_HUMAN

NCBI Description

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008]

Uniprot Description

TIMP4: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP- 9. Belongs to the protease inhibitor I35 (TIMP) family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3p25

Cellular Component: extracellular space; proteinaceous extracellular matrix; sarcomere

Molecular Function: metalloendopeptidase inhibitor activity; protease binding; metal ion binding

Biological Process: response to drug; response to peptide hormone stimulus; negative regulation of metalloenzyme activity; ovulation cycle; central nervous system development; response to cytokine stimulus; response to hormone stimulus; response to lipopolysaccharide; negative regulation of membrane protein ectodomain proteolysis