Immunohistochemistry (IHC)
Mouse Cytokeratin 13 Monoclonal Antibody | anti-KRT13 antibody
Mouse Anti-Cytokeratin 13 [AE8]
Reactivity
Mouse, Rabbit, Human
Applications
Western Blot, Immunohistochemistry
Purity
Protein G purified
Synonyms
Cytokeratin 13; Monoclonal Antibody; Mouse Anti-Cytokeratin 13 [AE8]; type I cytoskeletal 13 antibody; 47 kDa cytokeratin antibody; CK 13 antibody; CK-13antibody; CK13 antibody; Cytokeratin 13 antibody; Cytokeratin-13 antibody; Cytokeratin13 antibody; K13antibody; K1C13_HUMAN antibody; Ka13 antibody; Keratin 13 antibody; Keratin antibody; keratin type Icytoskeletal 13 antibody; Keratin-13 antibody; Keratin13 antibody; KRT 13 antibody; Krt-1.13 antibody; Krt1-13antibody; KRT13 antibody; MGC161462 antibody; MGC3781 antibody; Type I keratin Ka13 antibody; anti-KRT13 antibody
Host
Mouse
Reactivity
Mouse, Rabbit, Human
Clonality
Monoclonal
Isotype
Ig
Clone Number
AE8
Purity/Purification
Protein G purified
Form/Format
Purified antibody containing PBS 0.1% sodium azide;
Concentration
0.7mg/ml (varies by lot)
Sequence Length
420
Applicable Applications for anti-KRT13 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Application Notes
Optimal antibody dilution should be determined by titration, however as guideline try at WB: 1/1000 - 1/3000. Predicted molecular weight: 50 kDa
Target Antigen
Cytokeratin 13
Immunogen
Rabbit esophageal keratins
Myeloma/fusion Partners
P3 x 63 Ag8 myeloma cells
Research Areas
Cell Biology; Cytokeratins; Cytoskeleton; Cytoskeleton / ECM; Tags Cell Markers
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
References
Expression of hairrelated keratins in a soft epithelium: subpopulations of human and mouse dorsal tongue keratinocytes express keratin markers for hair, skin and esophagealtypes of differentiation. Dhouailly D (Exp Cell Res.,Mar 1998) PMID: 2465162 Parikh N et al. Mouse Tissues that Undergo Neoplastic Progression after K-Ras Activation Are Distinguished by Nuclear Translocation of phospho-Erk1/2 and Robust Tumor Suppressor Responses. Mol Cancer Res 10:845-55 (2012). IHC-P PMID: 22532587 Alameda JP et al. An inactivating CYLD mutation promotes skin tumor progression by conferring enhanced proliferative, survival and angiogenic properties to epidermal cancer cells. Oncogene 29:6522-32 (2010). IHC-P ; Human PMID: 20838385 Moreno-Maldonado R et al. IKKalpha enhances human keratinocyte differentiation and determines the histological variant of epidermal squamous cell carcinomas. Cell Cycle 7:2021-9 (2008). IHC-P ; Human PMID: 18604171 Leedham SJ et al. Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett's oesophagus. Gut 57:1041-8 (2008). ICC/IF ; Human PMID: 18305067 Parikh N et al. Isolation and characterization of an immortalized oral keratinocyte cell line of mouse origin. Arch Oral Biol 53:1091-100 (2008) PMID: 18721915 Kimball JR et al. Antimicrobial barrier of an in vitro oral epithelial model. Arch Oral Biol 51:775-83 (2006)PMID:16815238 Wada-Hiraike O et al. Role of estrogen receptor beta in uterine stroma and epithelium: Insights from estrogen receptor beta-/- mice. Proc Natl Acad Sci U S A 103:18350-5 (2006). IHC-P ; Mouse PMID: 17110437
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
45,867 Da
NCBI Official Full Name
cytokeratin 13
UniProt Protein Name
Keratin, type I cytoskeletal 13
Protein Family
UniProt Gene Name
KRT13
UniProt Synonym Gene Names
CK-13; K13
UniProt Entry Name
K1C13_HUMAN
Uniprot Description
K13: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K4
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: intermediate filament cytoskeleton; keratin filament; nucleus
Molecular Function: structural molecule activity
Biological Process: response to radiation; tongue morphogenesis; cytoskeleton organization and biogenesis
Disease: White Sponge Nevus 2
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Product Notes
The Cytokeratin 13 krt13 (Catalog #AAA375184) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Cytokeratin 13 [AE8] reacts with Mouse, Rabbit, Human and may cross-react with other species as described in the data sheet. AAA Biotech's Cytokeratin 13 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Optimal antibody dilution should be determined by titration, however as guideline try at WB: 1/1000 - 1/3000. Predicted molecular weight: 50 kDa. Researchers should empirically determine the suitability of the Cytokeratin 13 krt13 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cytokeratin 13, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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